Persistent polyclonal B-cell lymphocytosis in a woman with bone marrow involvement by breast cancer

Giovanni D'Arena, Luigi Del Vecchio, Gianpaolo Marcacci, Annarosaria De Chiara, Paolo Morabito, Maria Luigia Vigliotti, Adriano Gravina, Raffaele Di Francia, Gino Svanera, Giancarla Iaccarino, Antonio Pinto

Research output: Contribution to journalArticle

Abstract

We described a case of an "atypical" form of PPBL in a non-smoker woman suffering from bone marrow involvement by breast cancer with circulating mononucleated polyclonal B-lymphocytes without polyclonal increase in serum IgM and cytogenetic abnormalities. Whether a PPBL may appear as a reaction to a bone marrow involvement of breast cancer or may be a pre-neoplastic entity, preceding the emergence of a predominant clone, is not completely understood. Lately, because of the natural history of PPBL still remain unclear, these patients need to undergo a careful and continued long follow-up.

Original languageEnglish
Pages (from-to)697-700
Number of pages4
JournalHAEMA
Volume9
Issue number5
Publication statusPublished - 2006

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Bone Marrow
Breast Neoplasms
Natural History
Chromosome Aberrations
Immunoglobulin M
B-Lymphocytes
Clone Cells
Serum
Persistent Polyclonal B-Cell Lymphocytosis

ASJC Scopus subject areas

  • Hematology

Cite this

Persistent polyclonal B-cell lymphocytosis in a woman with bone marrow involvement by breast cancer. / D'Arena, Giovanni; Del Vecchio, Luigi; Marcacci, Gianpaolo; De Chiara, Annarosaria; Morabito, Paolo; Vigliotti, Maria Luigia; Gravina, Adriano; Di Francia, Raffaele; Svanera, Gino; Iaccarino, Giancarla; Pinto, Antonio.

In: HAEMA, Vol. 9, No. 5, 2006, p. 697-700.

Research output: Contribution to journalArticle

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AU - Del Vecchio, Luigi

AU - Marcacci, Gianpaolo

AU - De Chiara, Annarosaria

AU - Morabito, Paolo

AU - Vigliotti, Maria Luigia

AU - Gravina, Adriano

AU - Di Francia, Raffaele

AU - Svanera, Gino

AU - Iaccarino, Giancarla

AU - Pinto, Antonio

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