Persistent rhinovirus infection in pediatric hematopoietic stem cell transplant recipients with impaired cellular immunity

Antonio Piralla, Marco Zecca, Patrizia Comoli, Alessia Girello, Rita Maccario, Fausto Baldanti

Research output: Contribution to journalArticlepeer-review

Abstract

Background: HRV infections are generally self-limiting in healthy subjects, whereas in immunocompromised hosts HRV infections can lead to severe complications and persistent infections. The persistence of HRV shedding could be due to the inefficient immunological control of a single infectious episode. Objectives: To investigate the clinical, virologic and immunologic characteristics of pediatric HSCT recipients with HRV-PI infection. Study design: During the period 2006-2012, eight hematopoietic stem cell transplant (HSCT) recipients presented with persistent rhinovirus infection (HRV-PI, ≥30 days). Viral load and T-CD4+, T-CD8+, B and NK lymphocyte counts at the onset of infection were compared with those of fourteen HSCT recipients with acute HRV infection (HRV-AI, ≤15 days). Results: The median duration of HRV positivity in patients with HRV-PI was 61 days (range 30-174 days) and phylogenetic analysis showed the persistence of a single HRV type in all patients (100%). In HSCT recipients with HRV-PI, T-CD4+, T-CD8+ and NK cell counts at the onset of infection were significantly lower than those observed in recipients with HRV-AI (p+, T-CD8+and NK lymphocyte counts in HRV-PI patients (p

Original languageEnglish
Pages (from-to)38-42
Number of pages5
JournalJournal of Clinical Virology
Volume67
DOIs
Publication statusPublished - Jun 1 2015

Keywords

  • Cellular immunity
  • Hematopoietic stem cell transplant recipients
  • HRV persistent infection
  • Immunocompromised pediatric patients

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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