Persistent symptomless human metapneumovirus infection in hematopoietic stem cell transplant recipients

Maurizia Debiaggi, Filippo Canducci, Michela Sampaolo, Maria Chiara Marinozzi, Maurizio Parea, Cristina Terulla, Anna Amelia Colombo, Emilio Paolo Alessandrino, Letizia Zenone Bragotti, Milena Arghittu, Antonio Goglio, Roberta Migliavacca, Egidio Romero, Massimo Clementi

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

Sequential nasopharyngeal aspirates from patients without respiratory symptoms undergoing hematopoietic stem cell transplantation (HSCT) were tested for genomic RNA of human metapneumovirus (hMPV). Persistent hMPV infection was documented in most of them and confirmed by virus isolation. hMPV infection etiology was also evaluated during the same period in samples from pediatric patients with acute respiratory diseases (ARDs). Sequence analysis of hMPV in HSCT recipients documented infection by hMPV genotype A and strong interhost similarity; this pattern differs from that observed in pediatric patients with ARDs. The data indicate that HSCT recipients may frequently develop symptomless hMPV infection.

Original languageEnglish
Pages (from-to)474-478
Number of pages5
JournalJournal of Infectious Diseases
Volume194
Issue number4
DOIs
Publication statusPublished - Aug 15 2006

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Metapneumovirus
Hematopoietic Stem Cells
Transplants
Hematopoietic Stem Cell Transplantation
Infection
Acute Disease
Pediatrics
Sequence Analysis
Transplant Recipients
Genotype
RNA
Viruses

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

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Persistent symptomless human metapneumovirus infection in hematopoietic stem cell transplant recipients. / Debiaggi, Maurizia; Canducci, Filippo; Sampaolo, Michela; Marinozzi, Maria Chiara; Parea, Maurizio; Terulla, Cristina; Colombo, Anna Amelia; Alessandrino, Emilio Paolo; Bragotti, Letizia Zenone; Arghittu, Milena; Goglio, Antonio; Migliavacca, Roberta; Romero, Egidio; Clementi, Massimo.

In: Journal of Infectious Diseases, Vol. 194, No. 4, 15.08.2006, p. 474-478.

Research output: Contribution to journalArticle

Debiaggi, M, Canducci, F, Sampaolo, M, Marinozzi, MC, Parea, M, Terulla, C, Colombo, AA, Alessandrino, EP, Bragotti, LZ, Arghittu, M, Goglio, A, Migliavacca, R, Romero, E & Clementi, M 2006, 'Persistent symptomless human metapneumovirus infection in hematopoietic stem cell transplant recipients', Journal of Infectious Diseases, vol. 194, no. 4, pp. 474-478. https://doi.org/10.1086/505881
Debiaggi, Maurizia ; Canducci, Filippo ; Sampaolo, Michela ; Marinozzi, Maria Chiara ; Parea, Maurizio ; Terulla, Cristina ; Colombo, Anna Amelia ; Alessandrino, Emilio Paolo ; Bragotti, Letizia Zenone ; Arghittu, Milena ; Goglio, Antonio ; Migliavacca, Roberta ; Romero, Egidio ; Clementi, Massimo. / Persistent symptomless human metapneumovirus infection in hematopoietic stem cell transplant recipients. In: Journal of Infectious Diseases. 2006 ; Vol. 194, No. 4. pp. 474-478.
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