Personalized, bilateral whole-body somatosensory cortex stimulation to relieve fatigue in multiple sclerosis

Andrea Cancelli, Carlo Cottone, Alessandro Giordani, Simone Migliore, Domenico Lupoi, Camillo Porcaro, Massimiliano Mirabella, Paolo Maria Rossini, Maria Maddalena Filippi, Franca Tecchio

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: The patients suffering from multiple sclerosis (MS) often consider fatigue the most debilitating symptom they experience, but conventional medicine currently offers poorly efficacious therapies. Objective: We executed a replication study of an innovative approach for relieving MS fatigue. Methods: According to the sample size estimate, we recruited 10 fatigued MS patients who received 5-day transcranial direct current stimulation (tDCS) in a randomized, double-blind, Sham-controlled, crossover study, with modified Fatigue Impact Scale (mFIS) score reduction at the end of the treatment as primary outcome. A personalized anodal electrode, shaped on the magnetic resonance imaging (MRI)-derived individual cortical folding, targeted the bilateral whole-body primary somatosensory cortex (S1) with an occipital cathode. Results: The amelioration of fatigue symptoms after Real stimulation (40% of baseline) was significantly larger than after Sham stimulation (14%, p = 0.012). Anodal whole body S1 induced a significant fatigue reduction in mildly disabled MS patients when the fatigue-related symptoms severely hampered their quality of life. Conclusion: This second result in an independent group of patients supports the idea that neuromodulation interventions that properly select a personalized target might be a suitable non-pharmacological treatment for MS fatigue.

Original languageEnglish
Pages (from-to)1366-1374
Number of pages9
JournalMultiple Sclerosis Journal
Volume24
Issue number10
DOIs
Publication statusPublished - Sep 1 2018

Fingerprint

Somatosensory Cortex
Multiple Sclerosis
Fatigue
Electrodes
Sample Size
Cross-Over Studies
Therapeutics
Quality of Life
Magnetic Resonance Imaging
Medicine

Keywords

  • fatigue
  • Multiple sclerosis
  • quality of life
  • regional personalized electrode (RePE)
  • transcranial direct current stimulation (tDCS)

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Cancelli, A., Cottone, C., Giordani, A., Migliore, S., Lupoi, D., Porcaro, C., ... Tecchio, F. (2018). Personalized, bilateral whole-body somatosensory cortex stimulation to relieve fatigue in multiple sclerosis. Multiple Sclerosis Journal, 24(10), 1366-1374. https://doi.org/10.1177/1352458517720528

Personalized, bilateral whole-body somatosensory cortex stimulation to relieve fatigue in multiple sclerosis. / Cancelli, Andrea; Cottone, Carlo; Giordani, Alessandro; Migliore, Simone; Lupoi, Domenico; Porcaro, Camillo; Mirabella, Massimiliano; Rossini, Paolo Maria; Filippi, Maria Maddalena; Tecchio, Franca.

In: Multiple Sclerosis Journal, Vol. 24, No. 10, 01.09.2018, p. 1366-1374.

Research output: Contribution to journalArticle

Cancelli, A, Cottone, C, Giordani, A, Migliore, S, Lupoi, D, Porcaro, C, Mirabella, M, Rossini, PM, Filippi, MM & Tecchio, F 2018, 'Personalized, bilateral whole-body somatosensory cortex stimulation to relieve fatigue in multiple sclerosis', Multiple Sclerosis Journal, vol. 24, no. 10, pp. 1366-1374. https://doi.org/10.1177/1352458517720528
Cancelli, Andrea ; Cottone, Carlo ; Giordani, Alessandro ; Migliore, Simone ; Lupoi, Domenico ; Porcaro, Camillo ; Mirabella, Massimiliano ; Rossini, Paolo Maria ; Filippi, Maria Maddalena ; Tecchio, Franca. / Personalized, bilateral whole-body somatosensory cortex stimulation to relieve fatigue in multiple sclerosis. In: Multiple Sclerosis Journal. 2018 ; Vol. 24, No. 10. pp. 1366-1374.
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