Personalized, bilateral whole-body somatosensory cortex stimulation to relieve fatigue in multiple sclerosis

Andrea Cancelli, Carlo Cottone, Alessandro Giordani, Simone Migliore, Domenico Lupoi, Camillo Porcaro, Massimiliano Mirabella, Paolo Maria Rossini, Maria Maddalena Filippi, Franca Tecchio

Research output: Contribution to journalArticlepeer-review


Background: The patients suffering from multiple sclerosis (MS) often consider fatigue the most debilitating symptom they experience, but conventional medicine currently offers poorly efficacious therapies. Objective: We executed a replication study of an innovative approach for relieving MS fatigue. Methods: According to the sample size estimate, we recruited 10 fatigued MS patients who received 5-day transcranial direct current stimulation (tDCS) in a randomized, double-blind, Sham-controlled, crossover study, with modified Fatigue Impact Scale (mFIS) score reduction at the end of the treatment as primary outcome. A personalized anodal electrode, shaped on the magnetic resonance imaging (MRI)-derived individual cortical folding, targeted the bilateral whole-body primary somatosensory cortex (S1) with an occipital cathode. Results: The amelioration of fatigue symptoms after Real stimulation (40% of baseline) was significantly larger than after Sham stimulation (14%, p = 0.012). Anodal whole body S1 induced a significant fatigue reduction in mildly disabled MS patients when the fatigue-related symptoms severely hampered their quality of life. Conclusion: This second result in an independent group of patients supports the idea that neuromodulation interventions that properly select a personalized target might be a suitable non-pharmacological treatment for MS fatigue.

Original languageEnglish
Pages (from-to)1366-1374
Number of pages9
JournalMultiple Sclerosis Journal
Issue number10
Publication statusPublished - Sep 1 2018


  • fatigue
  • Multiple sclerosis
  • quality of life
  • regional personalized electrode (RePE)
  • transcranial direct current stimulation (tDCS)

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


Dive into the research topics of 'Personalized, bilateral whole-body somatosensory cortex stimulation to relieve fatigue in multiple sclerosis'. Together they form a unique fingerprint.

Cite this