Abstract
Background: The patients suffering from multiple sclerosis (MS) often consider fatigue the most debilitating symptom they experience, but conventional medicine currently offers poorly efficacious therapies. Objective: We executed a replication study of an innovative approach for relieving MS fatigue. Methods: According to the sample size estimate, we recruited 10 fatigued MS patients who received 5-day transcranial direct current stimulation (tDCS) in a randomized, double-blind, Sham-controlled, crossover study, with modified Fatigue Impact Scale (mFIS) score reduction at the end of the treatment as primary outcome. A personalized anodal electrode, shaped on the magnetic resonance imaging (MRI)-derived individual cortical folding, targeted the bilateral whole-body primary somatosensory cortex (S1) with an occipital cathode. Results: The amelioration of fatigue symptoms after Real stimulation (40% of baseline) was significantly larger than after Sham stimulation (14%, p = 0.012). Anodal whole body S1 induced a significant fatigue reduction in mildly disabled MS patients when the fatigue-related symptoms severely hampered their quality of life. Conclusion: This second result in an independent group of patients supports the idea that neuromodulation interventions that properly select a personalized target might be a suitable non-pharmacological treatment for MS fatigue.
| Original language | English |
|---|---|
| Pages (from-to) | 1366-1374 |
| Number of pages | 9 |
| Journal | Multiple Sclerosis Journal |
| Volume | 24 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - Sep 1 2018 |
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Keywords
- fatigue
- Multiple sclerosis
- quality of life
- regional personalized electrode (RePE)
- transcranial direct current stimulation (tDCS)
ASJC Scopus subject areas
- Neurology
- Clinical Neurology
Cite this
Personalized, bilateral whole-body somatosensory cortex stimulation to relieve fatigue in multiple sclerosis. / Cancelli, Andrea; Cottone, Carlo; Giordani, Alessandro; Migliore, Simone; Lupoi, Domenico; Porcaro, Camillo; Mirabella, Massimiliano; Rossini, Paolo Maria; Filippi, Maria Maddalena; Tecchio, Franca.
In: Multiple Sclerosis Journal, Vol. 24, No. 10, 01.09.2018, p. 1366-1374.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Personalized, bilateral whole-body somatosensory cortex stimulation to relieve fatigue in multiple sclerosis
AU - Cancelli, Andrea
AU - Cottone, Carlo
AU - Giordani, Alessandro
AU - Migliore, Simone
AU - Lupoi, Domenico
AU - Porcaro, Camillo
AU - Mirabella, Massimiliano
AU - Rossini, Paolo Maria
AU - Filippi, Maria Maddalena
AU - Tecchio, Franca
PY - 2018/9/1
Y1 - 2018/9/1
N2 - Background: The patients suffering from multiple sclerosis (MS) often consider fatigue the most debilitating symptom they experience, but conventional medicine currently offers poorly efficacious therapies. Objective: We executed a replication study of an innovative approach for relieving MS fatigue. Methods: According to the sample size estimate, we recruited 10 fatigued MS patients who received 5-day transcranial direct current stimulation (tDCS) in a randomized, double-blind, Sham-controlled, crossover study, with modified Fatigue Impact Scale (mFIS) score reduction at the end of the treatment as primary outcome. A personalized anodal electrode, shaped on the magnetic resonance imaging (MRI)-derived individual cortical folding, targeted the bilateral whole-body primary somatosensory cortex (S1) with an occipital cathode. Results: The amelioration of fatigue symptoms after Real stimulation (40% of baseline) was significantly larger than after Sham stimulation (14%, p = 0.012). Anodal whole body S1 induced a significant fatigue reduction in mildly disabled MS patients when the fatigue-related symptoms severely hampered their quality of life. Conclusion: This second result in an independent group of patients supports the idea that neuromodulation interventions that properly select a personalized target might be a suitable non-pharmacological treatment for MS fatigue.
AB - Background: The patients suffering from multiple sclerosis (MS) often consider fatigue the most debilitating symptom they experience, but conventional medicine currently offers poorly efficacious therapies. Objective: We executed a replication study of an innovative approach for relieving MS fatigue. Methods: According to the sample size estimate, we recruited 10 fatigued MS patients who received 5-day transcranial direct current stimulation (tDCS) in a randomized, double-blind, Sham-controlled, crossover study, with modified Fatigue Impact Scale (mFIS) score reduction at the end of the treatment as primary outcome. A personalized anodal electrode, shaped on the magnetic resonance imaging (MRI)-derived individual cortical folding, targeted the bilateral whole-body primary somatosensory cortex (S1) with an occipital cathode. Results: The amelioration of fatigue symptoms after Real stimulation (40% of baseline) was significantly larger than after Sham stimulation (14%, p = 0.012). Anodal whole body S1 induced a significant fatigue reduction in mildly disabled MS patients when the fatigue-related symptoms severely hampered their quality of life. Conclusion: This second result in an independent group of patients supports the idea that neuromodulation interventions that properly select a personalized target might be a suitable non-pharmacological treatment for MS fatigue.
KW - fatigue
KW - Multiple sclerosis
KW - quality of life
KW - regional personalized electrode (RePE)
KW - transcranial direct current stimulation (tDCS)
UR - http://www.scopus.com/inward/record.url?scp=85042838722&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85042838722&partnerID=8YFLogxK
U2 - 10.1177/1352458517720528
DO - 10.1177/1352458517720528
M3 - Article
AN - SCOPUS:85042838722
VL - 24
SP - 1366
EP - 1374
JO - Multiple Sclerosis
JF - Multiple Sclerosis
SN - 1352-4585
IS - 10
ER -