Personalized laboratory medicine: A patient-centered future approach

I Prodan Žitnik, D Černe, I Mancini, L Simi, M Pazzagli, C Di Resta, H Podgornik, B Repič Lampret, K Trebušak Podkrajšek, C Sipeky, R Van Schaik, I Brandslund, P Vermeersch, M Schwab, J Marc, on behalf of EFLM/ESPT working group of Personalised Laboratory Medicine

Research output: Contribution to journalArticle

Abstract

In contrast to population-based medical decision making, which emphasizes the use of evidence-based treatment strategies for groups of patients, personalized medicine is based on optimizing treatment at the level of the individual patient. The creation of molecular profiles of individual patients was made possible by the advent of "omics" technologies, based on high throughput instrumental techniques in combination with biostatistics tools and artificial intelligence. The goal of personalized laboratory medicine is to use advanced technologies in the process of preventive, curative or palliative patient management. Personalized medicine does not rely on changes in concentration of a single molecular marker to make a therapeutic decision, but rather on changes of a profile of markers characterizing an individual patient's status, taking into account not only the expected response to treatment of the disease but also the expected response of the patient. Such medical approach promises a more effective diagnostics with more effective and safer treatment, as well as faster recovery and restoration of health and improved cost effectiveness. The laboratory medicine profession is aware of its key role in personalized medicine, but to empower the laboratories, at least an enhancement in cooperation between disciplines within laboratory medicine will be necessary. ©2018 Walter de Gruyter GmbH, Berlin/Boston 2018.
Original languageEnglish
Pages (from-to)1981-1991
Number of pages11
JournalClinical Chemistry and Laboratory Medicine
Volume56
Issue number12
DOIs
Publication statusPublished - 2018

Fingerprint

Precision Medicine
Medicine
Biostatistics
Technology
Therapeutics
Artificial Intelligence
Berlin
Cost effectiveness
Health Care Costs
Restoration
Cost-Benefit Analysis
Artificial intelligence
Decision making
Throughput
Health
Recovery
Population

Cite this

Prodan Žitnik, I., Černe, D., Mancini, I., Simi, L., Pazzagli, M., Di Resta, C., ... Medicine, O. B. O. EFLMESPT. W. G. O. P. L. (2018). Personalized laboratory medicine: A patient-centered future approach. Clinical Chemistry and Laboratory Medicine, 56(12), 1981-1991. https://doi.org/10.1515/cclm-2018-0181

Personalized laboratory medicine: A patient-centered future approach. / Prodan Žitnik, I; Černe, D; Mancini, I; Simi, L; Pazzagli, M; Di Resta, C; Podgornik, H; Repič Lampret, B; Trebušak Podkrajšek, K; Sipeky, C; Van Schaik, R; Brandslund, I; Vermeersch, P; Schwab, M; Marc, J; Medicine, on behalf of EFLM/ESPT working group of Personalised Laboratory.

In: Clinical Chemistry and Laboratory Medicine, Vol. 56, No. 12, 2018, p. 1981-1991.

Research output: Contribution to journalArticle

Prodan Žitnik, I, Černe, D, Mancini, I, Simi, L, Pazzagli, M, Di Resta, C, Podgornik, H, Repič Lampret, B, Trebušak Podkrajšek, K, Sipeky, C, Van Schaik, R, Brandslund, I, Vermeersch, P, Schwab, M, Marc, J & Medicine, OBOEFLMESPTWGOPL 2018, 'Personalized laboratory medicine: A patient-centered future approach', Clinical Chemistry and Laboratory Medicine, vol. 56, no. 12, pp. 1981-1991. https://doi.org/10.1515/cclm-2018-0181
Prodan Žitnik I, Černe D, Mancini I, Simi L, Pazzagli M, Di Resta C et al. Personalized laboratory medicine: A patient-centered future approach. Clinical Chemistry and Laboratory Medicine. 2018;56(12):1981-1991. https://doi.org/10.1515/cclm-2018-0181
Prodan Žitnik, I ; Černe, D ; Mancini, I ; Simi, L ; Pazzagli, M ; Di Resta, C ; Podgornik, H ; Repič Lampret, B ; Trebušak Podkrajšek, K ; Sipeky, C ; Van Schaik, R ; Brandslund, I ; Vermeersch, P ; Schwab, M ; Marc, J ; Medicine, on behalf of EFLM/ESPT working group of Personalised Laboratory. / Personalized laboratory medicine: A patient-centered future approach. In: Clinical Chemistry and Laboratory Medicine. 2018 ; Vol. 56, No. 12. pp. 1981-1991.
@article{ab3227991a524cf09c905324f655971b,
title = "Personalized laboratory medicine: A patient-centered future approach",
abstract = "In contrast to population-based medical decision making, which emphasizes the use of evidence-based treatment strategies for groups of patients, personalized medicine is based on optimizing treatment at the level of the individual patient. The creation of molecular profiles of individual patients was made possible by the advent of {"}omics{"} technologies, based on high throughput instrumental techniques in combination with biostatistics tools and artificial intelligence. The goal of personalized laboratory medicine is to use advanced technologies in the process of preventive, curative or palliative patient management. Personalized medicine does not rely on changes in concentration of a single molecular marker to make a therapeutic decision, but rather on changes of a profile of markers characterizing an individual patient's status, taking into account not only the expected response to treatment of the disease but also the expected response of the patient. Such medical approach promises a more effective diagnostics with more effective and safer treatment, as well as faster recovery and restoration of health and improved cost effectiveness. The laboratory medicine profession is aware of its key role in personalized medicine, but to empower the laboratories, at least an enhancement in cooperation between disciplines within laboratory medicine will be necessary. {\circledC}2018 Walter de Gruyter GmbH, Berlin/Boston 2018.",
author = "{Prodan Žitnik}, I and D Černe and I Mancini and L Simi and M Pazzagli and {Di Resta}, C and H Podgornik and {Repič Lampret}, B and {Trebušak Podkrajšek}, K and C Sipeky and {Van Schaik}, R and I Brandslund and P Vermeersch and M Schwab and J Marc and Medicine, {on behalf of EFLM/ESPT working group of Personalised Laboratory}",
year = "2018",
doi = "10.1515/cclm-2018-0181",
language = "English",
volume = "56",
pages = "1981--1991",
journal = "Clinical Chemistry and Laboratory Medicine",
issn = "1434-6621",
publisher = "Walter de Gruyter GmbH",
number = "12",

}

TY - JOUR

T1 - Personalized laboratory medicine: A patient-centered future approach

AU - Prodan Žitnik, I

AU - Černe, D

AU - Mancini, I

AU - Simi, L

AU - Pazzagli, M

AU - Di Resta, C

AU - Podgornik, H

AU - Repič Lampret, B

AU - Trebušak Podkrajšek, K

AU - Sipeky, C

AU - Van Schaik, R

AU - Brandslund, I

AU - Vermeersch, P

AU - Schwab, M

AU - Marc, J

AU - Medicine, on behalf of EFLM/ESPT working group of Personalised Laboratory

PY - 2018

Y1 - 2018

N2 - In contrast to population-based medical decision making, which emphasizes the use of evidence-based treatment strategies for groups of patients, personalized medicine is based on optimizing treatment at the level of the individual patient. The creation of molecular profiles of individual patients was made possible by the advent of "omics" technologies, based on high throughput instrumental techniques in combination with biostatistics tools and artificial intelligence. The goal of personalized laboratory medicine is to use advanced technologies in the process of preventive, curative or palliative patient management. Personalized medicine does not rely on changes in concentration of a single molecular marker to make a therapeutic decision, but rather on changes of a profile of markers characterizing an individual patient's status, taking into account not only the expected response to treatment of the disease but also the expected response of the patient. Such medical approach promises a more effective diagnostics with more effective and safer treatment, as well as faster recovery and restoration of health and improved cost effectiveness. The laboratory medicine profession is aware of its key role in personalized medicine, but to empower the laboratories, at least an enhancement in cooperation between disciplines within laboratory medicine will be necessary. ©2018 Walter de Gruyter GmbH, Berlin/Boston 2018.

AB - In contrast to population-based medical decision making, which emphasizes the use of evidence-based treatment strategies for groups of patients, personalized medicine is based on optimizing treatment at the level of the individual patient. The creation of molecular profiles of individual patients was made possible by the advent of "omics" technologies, based on high throughput instrumental techniques in combination with biostatistics tools and artificial intelligence. The goal of personalized laboratory medicine is to use advanced technologies in the process of preventive, curative or palliative patient management. Personalized medicine does not rely on changes in concentration of a single molecular marker to make a therapeutic decision, but rather on changes of a profile of markers characterizing an individual patient's status, taking into account not only the expected response to treatment of the disease but also the expected response of the patient. Such medical approach promises a more effective diagnostics with more effective and safer treatment, as well as faster recovery and restoration of health and improved cost effectiveness. The laboratory medicine profession is aware of its key role in personalized medicine, but to empower the laboratories, at least an enhancement in cooperation between disciplines within laboratory medicine will be necessary. ©2018 Walter de Gruyter GmbH, Berlin/Boston 2018.

U2 - 10.1515/cclm-2018-0181

DO - 10.1515/cclm-2018-0181

M3 - Article

VL - 56

SP - 1981

EP - 1991

JO - Clinical Chemistry and Laboratory Medicine

JF - Clinical Chemistry and Laboratory Medicine

SN - 1434-6621

IS - 12

ER -