Personalizing surgical margins in retroperitoneal sarcomas

Research output: Contribution to journalArticlepeer-review


Retroperitoneal sarcomas are a group of diseases that behave differently from one another. Well-differentiated liposarcomas have an indolent biology but show a tendency to recur locally even years after primary resection. Dedifferentiated liposarcomas are characterized by a very high local recurrence risk, while the metastatic risk mainly depends on the histological characteristics of the dedifferentiated component. In leiomyosarcomas, hematogenous spread informs prognosis while local recurrences are far less common. Surgery is the cornerstone of treatment of all retroperitoneal sarcoma subtypes and its quality is the only treatment-related factor able to improve the oncological outcome. A frontline extended surgical approach is all the more critical in subtypes in which local control directly impacts prognosis.

Original languageEnglish
Pages (from-to)553-567
Number of pages15
JournalExpert Review of Anticancer Therapy
Issue number5
Publication statusPublished - May 1 2015


  • leiomyosarcoma
  • liposarcoma
  • outcome
  • prognosis
  • retroperitoneal sarcoma
  • sarcoma
  • solitary fibrous tumor
  • surgery
  • surgical margins

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Oncology
  • Medicine(all)


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