Abstract
Increasing data indicate that reduction of virus fitness may be beneficial for the host in persistent human infections caused by RNA viruses, and that virus fitness can be targeted in clinical practice. Analysis of virus fitness determinants in rapidly evolving RNA viruses has revealed that virus extinction may be obtained in vitro by forcing virus populations through a lethal mutagenesis process, thus abolishing virus replication by violation of the error threshold. It will be important in the future to evaluate the use of novel compounds designed specifically to modulate virus fitness in vivo, and to optimise diagnostic virology methods to enable a reliable large-scale evaluation of this approach.
| Original language | English |
|---|---|
| Pages (from-to) | 629-631 |
| Number of pages | 3 |
| Journal | Clinical Microbiology and Infection |
| Volume | 14 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - Jul 2008 |
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Keywords
- Fitness
- Human immunodeficiency virus
- Lethal mutagenesis
- Persistent infections
- Replication capacity
- RNA viruses
ASJC Scopus subject areas
- Microbiology (medical)
- Microbiology
- Infectious Diseases
Cite this
Perspectives and opportunities for novel antiviral treatments targeting virus fitness. / Clementi, Massimo.
In: Clinical Microbiology and Infection, Vol. 14, No. 7, 07.2008, p. 629-631.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Perspectives and opportunities for novel antiviral treatments targeting virus fitness
AU - Clementi, Massimo
PY - 2008/7
Y1 - 2008/7
N2 - Increasing data indicate that reduction of virus fitness may be beneficial for the host in persistent human infections caused by RNA viruses, and that virus fitness can be targeted in clinical practice. Analysis of virus fitness determinants in rapidly evolving RNA viruses has revealed that virus extinction may be obtained in vitro by forcing virus populations through a lethal mutagenesis process, thus abolishing virus replication by violation of the error threshold. It will be important in the future to evaluate the use of novel compounds designed specifically to modulate virus fitness in vivo, and to optimise diagnostic virology methods to enable a reliable large-scale evaluation of this approach.
AB - Increasing data indicate that reduction of virus fitness may be beneficial for the host in persistent human infections caused by RNA viruses, and that virus fitness can be targeted in clinical practice. Analysis of virus fitness determinants in rapidly evolving RNA viruses has revealed that virus extinction may be obtained in vitro by forcing virus populations through a lethal mutagenesis process, thus abolishing virus replication by violation of the error threshold. It will be important in the future to evaluate the use of novel compounds designed specifically to modulate virus fitness in vivo, and to optimise diagnostic virology methods to enable a reliable large-scale evaluation of this approach.
KW - Fitness
KW - Human immunodeficiency virus
KW - Lethal mutagenesis
KW - Persistent infections
KW - Replication capacity
KW - RNA viruses
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UR - http://www.scopus.com/inward/citedby.url?scp=45249120169&partnerID=8YFLogxK
U2 - 10.1111/j.1469-0691.2007.01937.x
DO - 10.1111/j.1469-0691.2007.01937.x
M3 - Article
VL - 14
SP - 629
EP - 631
JO - Clinical Microbiology and Infection
JF - Clinical Microbiology and Infection
SN - 1198-743X
IS - 7
ER -