Perspectives in clinical psychopharmacology of amitriptyline and fluvoxamine: A double-blind study in depressed inpatients

Mariangela Gasperini, Flavia Gatti, Laura Bellini, Roberta Anniverno, E. Smeraldi

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The efficacy of fluvoxamine was compared to that of amitriptyline in a double-blind 6-week fixed-dose trial of 56 inpatients with major depressive episode. The two drugs were comparable in their antidepressant efficacy. We tested the percentage of improvement in Hamilton-D scores during the first and the second weeks of treatment as predictors of efficacy for the last week. Improvement rates during the second week significantly predicted the outcome. We also investigated whether or not some symptomatological characteristics would permit prior prediction of the outcome with amitriptyline or fluvoxamine. dividing our sample into responders and nonresponders to the two drugs. The four groups showed differences in their symptomatological profiles.

Original languageEnglish
Pages (from-to)186-192
Number of pages7
JournalNeuropsychobiology
Volume26
Issue number4
DOIs
Publication statusPublished - 1992

Fingerprint

Fluvoxamine
Psychopharmacology
Amitriptyline
Double-Blind Method
Inpatients
Pharmaceutical Preparations
Antidepressive Agents
Therapeutics

Keywords

  • Antidepressant treatment
  • Fluvoxamine
  • Major depression
  • Prediction of drug efficacy

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)
  • Psychology(all)

Cite this

Perspectives in clinical psychopharmacology of amitriptyline and fluvoxamine : A double-blind study in depressed inpatients. / Gasperini, Mariangela; Gatti, Flavia; Bellini, Laura; Anniverno, Roberta; Smeraldi, E.

In: Neuropsychobiology, Vol. 26, No. 4, 1992, p. 186-192.

Research output: Contribution to journalArticle

Gasperini, Mariangela ; Gatti, Flavia ; Bellini, Laura ; Anniverno, Roberta ; Smeraldi, E. / Perspectives in clinical psychopharmacology of amitriptyline and fluvoxamine : A double-blind study in depressed inpatients. In: Neuropsychobiology. 1992 ; Vol. 26, No. 4. pp. 186-192.
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