Perspectives en endométriose nouvelles approches physiopathologiques et implications thérapeutiques futures

Translated title of the contribution: Perspectives: New treatments and novel etiopathogenetic concepts

Research output: Contribution to journalArticlepeer-review

Abstract

Pathophysiology of deeply infiltrating endometriosis remains controversial whereas physiopathologic mechanism of superficial endometriosis is nearly demonstrated. Superficial peritoneal implants derive from adhesion and proliferation of endometrial cells regurgitated in peritoneum with retrograde menstruation. Peritoneal inflammation involving cytokines as TNFα and aromatase over-expression might be involved in the endometriosis invasion processus. Specific molecular defects of both eutopic and ectopic endometrium have been identified for each of the processes involved in the disease development. Aromatase inhibitors decrease endometriosis lesions in a mouse model of endometriosis which was induced surgically. Few studies report efficacy of aromatase inhibitors in human endometriosis. Theoretically, aromatase inhibitors should not be used alone in premenopausal women because of the resultant increase in gonadotropin levels. Nevertheless, in premenopausal women, aromatase inhibitors may be used in association with Gn-RH agonists. TNFα is a secretory factor of macrophages that is known to be increased in the peritoneal fluid of women with endometriosis. Granulosa cells from these women produce higher levels of TNFα. This cytokine can stimulate adhesion and proliferation of endometrial cells and enhances metalloproteasis expression, making thus endometrial cell invasion easier. It also stimulates angiogenesis by regulating expression of IL-8. TNFα is also cytotoxic to gametes. In mice and baboon models with induced endometriosis, anti- TNFα (TNF binding protein-1) decreases AFS score stage and reduces in size the endometriotic foci. No clinical assay has studied TNFα efficacy on human endometriosis.

Translated title of the contributionPerspectives: New treatments and novel etiopathogenetic concepts
Original languageFrench
JournalJournal de Gynecologie Obstetrique et Biologie de la Reproduction
Volume32
Issue number8 II
Publication statusPublished - Dec 2003

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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