Prospettive di terapia genica delle sindromi ischemiche degli arti inferiori

Translated title of the contribution: Perspectives of gene therapy for the treatment of peripheral arterial occlusive disease

Research output: Contribution to journalArticlepeer-review

Abstract

In recent years, new knowledge has been provided from the study of the biological mechanisms underlying the angiogenic process, i.e. the development of a new vasculature from preexisting blood vessels. These advances suggested a possible new approach for the therapy of peripheral obstructive arterial disease, based on the treatment of ischemic tissues with angiogenic growth factors. As demonstrated by experimental studies in animal models, a therapeutic effect can be reached as the newly formed vascular network, functioning as a biologic by-pass, restores a normal blood supply to the ischemic territories. New techniques of gene therapy proved effective in reaching sustained concentrations of angiogenic factors in the target tissues. This paper will briefly describe the methodological background, the results of the early clinical applications of angiogenic gene therapy and the open questions that need to be addressed before this new approach can be proposed as an effective option instead of existing medical and surgical therapies.

Translated title of the contributionPerspectives of gene therapy for the treatment of peripheral arterial occlusive disease
Original languageItalian
Pages (from-to)180-183
Number of pages4
JournalRecenti Progressi in Medicina
Volume92
Issue number3
Publication statusPublished - Mar 2001

ASJC Scopus subject areas

  • Medicine(all)

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