TY - JOUR
T1 - Perspectives on preoperative systemic treatment and breast conservative surgery
T2 - One step forward or two steps back?
AU - Rubio, I. T.
AU - Wyld, L.
AU - Cardoso, F.
AU - Curigliano, G.
AU - Kovacs, T.
AU - Poortmans, P.
AU - Cortes, J.
PY - 2018/10/1
Y1 - 2018/10/1
N2 - Preoperative systemic therapy (PST) has become an accepted treatment not only for locally advanced but also for early stage breast cancer patients. Clinical trials have demonstrated that the use of PST is equally to adjuvant treatments in terms of overall survival, and has the advantage of increasing rates of breast conservative surgery and rates of pathologic complete response, a surrogate endpoint for the effectiveness of systemic therapy. Initial studies have suggested higher rates of locoregional recurrence with this approach. However, the optimization of systemic and targeted therapy and the multidisciplinary care is key to achieving optimal outcomes in this setting.
AB - Preoperative systemic therapy (PST) has become an accepted treatment not only for locally advanced but also for early stage breast cancer patients. Clinical trials have demonstrated that the use of PST is equally to adjuvant treatments in terms of overall survival, and has the advantage of increasing rates of breast conservative surgery and rates of pathologic complete response, a surrogate endpoint for the effectiveness of systemic therapy. Initial studies have suggested higher rates of locoregional recurrence with this approach. However, the optimization of systemic and targeted therapy and the multidisciplinary care is key to achieving optimal outcomes in this setting.
KW - Locoregional recurrences
KW - Postoperative systemic therapy
KW - Surgery
UR - http://www.scopus.com/inward/record.url?scp=85053144277&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85053144277&partnerID=8YFLogxK
U2 - 10.1016/j.breast.2018.07.008
DO - 10.1016/j.breast.2018.07.008
M3 - Article
C2 - 30056250
AN - SCOPUS:85053144277
VL - 41
SP - 133
EP - 135
JO - Breast
JF - Breast
SN - 0960-9776
ER -