Pertussis immunization in HIV-1-infected infants: A model to assess the effects of repeated T cell-dependent antigen administrations on HIV-1 progression. Italian Register for HIV infection in children

Pier Angelo Tovo, Maurizio de Martino, Clara Gabiano, Luisa Galli, P. Osimani, D. De Mattia, P. Zizzadoro, M. Ruggeri, M. Masi, G. Dell'Erba, M. Lanari, I. Bosi, P. G. Chiriacò, M. Duse, P. Crispino, M. R. Soresina, E. Bresciani, L. Battisti, C. Pintor, F. ChiappeM. Belloni, D. Loriano, P. Ibba, R. Berrino, C. Nasi, M. Sticca, M. Palmieri, E. Anastasio, T. Bezzi, A. Vierucci, A. Guarino Amato, S. Farina, M. T. Cecchi, A. De Maria, F. Fioredda, E. Donelli, M. G. Marazzi, E. Pontali, G. L. Forni, D. Cosso, C. Gotta, D. Lobello, U. Tondo, E. Micheletti, C. Ruggeri, A. Plebani, R. Pinzani, F. Salvini, P. Marchisio, S. Esposito, E. Massironi, G. V. Zuccotti, E. Riva, A. Gamboni, G. Ferraris, L. Rancilio, C. Vegni, R. Altobelli, R. Lipreri, S. Conio, F. Lizzoli, G. Gambaretto, M. Cellini, C. Pignata, N. Pozzi, A. Guarino, A. Romano, A. Todeschini, C. Giaquinto, E. M. Ruga, O. Rampon, R. Consolini, G. Palla, A. Legitimo, G. Benaglia, D. Caselli, A. Maccabruni, I. Pacati, A. Antonellini, A. Metri, C. Magnani, P. Falconieri, C. Fundarò, O. Genovese, C. Rendeli, M. Stegagno, G. Castelli Gattinara, S. Bernardi, C. Cancrini, C. Timpano, G. Anzidei, M. R. Marchili, S. Catania, C. Ogana, A. Mazza, A. Di Palma, C. Scolfaro, C. Riva, E. Palomba, C. Salvatore

Research output: Contribution to journalArticle

Abstract

Several data evidence that HIV-1 replication may increase in temporal association with immunizations, raising concerns on potential negative effects of vaccinations on HIV-1 progression. Among patients prospectively followed by the 'Italian Register for HIV infection in children', we evaluated, using the Cox-Mantel method, conditional probabilities of progressing to CDC clinical categories 'B' or 'C', and immunological categories '2' or '3' in 88 children immunized against pertussis and 244 non- immunized. No selection criteria were followed in vaccinating children. No significant differences were observed between the two groups. The lack of a significant impact on clinical and immunological deterioration by the repeated administrations of a T cell-dependent vaccine endorses the current recommendations for routine immunizations in HIV-1-infected children.

Original languageEnglish
Pages (from-to)1203-1209
Number of pages7
JournalVaccine
Volume18
Issue number13
DOIs
Publication statusPublished - Jan 21 2000

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Whooping Cough
HIV infections
Human immunodeficiency virus 1
HIV Infections
HIV-1
Immunization
immunization
T-lymphocytes
antigens
T-Lymphocytes
Antigens
Centers for Disease Control and Prevention (U.S.)
selection criteria
Patient Selection
Vaccination
Vaccines
deterioration
vaccination
vaccines
methodology

Keywords

  • Disease progression
  • Perinatal HIV-1 infection
  • Pertussis immunization

ASJC Scopus subject areas

  • Immunology
  • Microbiology
  • Virology
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)

Cite this

Pertussis immunization in HIV-1-infected infants : A model to assess the effects of repeated T cell-dependent antigen administrations on HIV-1 progression. Italian Register for HIV infection in children. / Tovo, Pier Angelo; de Martino, Maurizio; Gabiano, Clara; Galli, Luisa; Osimani, P.; De Mattia, D.; Zizzadoro, P.; Ruggeri, M.; Masi, M.; Dell'Erba, G.; Lanari, M.; Bosi, I.; Chiriacò, P. G.; Duse, M.; Crispino, P.; Soresina, M. R.; Bresciani, E.; Battisti, L.; Pintor, C.; Chiappe, F.; Belloni, M.; Loriano, D.; Ibba, P.; Berrino, R.; Nasi, C.; Sticca, M.; Palmieri, M.; Anastasio, E.; Bezzi, T.; Vierucci, A.; Guarino Amato, A.; Farina, S.; Cecchi, M. T.; De Maria, A.; Fioredda, F.; Donelli, E.; Marazzi, M. G.; Pontali, E.; Forni, G. L.; Cosso, D.; Gotta, C.; Lobello, D.; Tondo, U.; Micheletti, E.; Ruggeri, C.; Plebani, A.; Pinzani, R.; Salvini, F.; Marchisio, P.; Esposito, S.; Massironi, E.; Zuccotti, G. V.; Riva, E.; Gamboni, A.; Ferraris, G.; Rancilio, L.; Vegni, C.; Altobelli, R.; Lipreri, R.; Conio, S.; Lizzoli, F.; Gambaretto, G.; Cellini, M.; Pignata, C.; Pozzi, N.; Guarino, A.; Romano, A.; Todeschini, A.; Giaquinto, C.; Ruga, E. M.; Rampon, O.; Consolini, R.; Palla, G.; Legitimo, A.; Benaglia, G.; Caselli, D.; Maccabruni, A.; Pacati, I.; Antonellini, A.; Metri, A.; Magnani, C.; Falconieri, P.; Fundarò, C.; Genovese, O.; Rendeli, C.; Stegagno, M.; Castelli Gattinara, G.; Bernardi, S.; Cancrini, C.; Timpano, C.; Anzidei, G.; Marchili, M. R.; Catania, S.; Ogana, C.; Mazza, A.; Di Palma, A.; Scolfaro, C.; Riva, C.; Palomba, E.; Salvatore, C.

In: Vaccine, Vol. 18, No. 13, 21.01.2000, p. 1203-1209.

Research output: Contribution to journalArticle

Tovo, PA, de Martino, M, Gabiano, C, Galli, L, Osimani, P, De Mattia, D, Zizzadoro, P, Ruggeri, M, Masi, M, Dell'Erba, G, Lanari, M, Bosi, I, Chiriacò, PG, Duse, M, Crispino, P, Soresina, MR, Bresciani, E, Battisti, L, Pintor, C, Chiappe, F, Belloni, M, Loriano, D, Ibba, P, Berrino, R, Nasi, C, Sticca, M, Palmieri, M, Anastasio, E, Bezzi, T, Vierucci, A, Guarino Amato, A, Farina, S, Cecchi, MT, De Maria, A, Fioredda, F, Donelli, E, Marazzi, MG, Pontali, E, Forni, GL, Cosso, D, Gotta, C, Lobello, D, Tondo, U, Micheletti, E, Ruggeri, C, Plebani, A, Pinzani, R, Salvini, F, Marchisio, P, Esposito, S, Massironi, E, Zuccotti, GV, Riva, E, Gamboni, A, Ferraris, G, Rancilio, L, Vegni, C, Altobelli, R, Lipreri, R, Conio, S, Lizzoli, F, Gambaretto, G, Cellini, M, Pignata, C, Pozzi, N, Guarino, A, Romano, A, Todeschini, A, Giaquinto, C, Ruga, EM, Rampon, O, Consolini, R, Palla, G, Legitimo, A, Benaglia, G, Caselli, D, Maccabruni, A, Pacati, I, Antonellini, A, Metri, A, Magnani, C, Falconieri, P, Fundarò, C, Genovese, O, Rendeli, C, Stegagno, M, Castelli Gattinara, G, Bernardi, S, Cancrini, C, Timpano, C, Anzidei, G, Marchili, MR, Catania, S, Ogana, C, Mazza, A, Di Palma, A, Scolfaro, C, Riva, C, Palomba, E & Salvatore, C 2000, 'Pertussis immunization in HIV-1-infected infants: A model to assess the effects of repeated T cell-dependent antigen administrations on HIV-1 progression. Italian Register for HIV infection in children', Vaccine, vol. 18, no. 13, pp. 1203-1209. https://doi.org/10.1016/S0264-410X(99)00383-7
Tovo, Pier Angelo ; de Martino, Maurizio ; Gabiano, Clara ; Galli, Luisa ; Osimani, P. ; De Mattia, D. ; Zizzadoro, P. ; Ruggeri, M. ; Masi, M. ; Dell'Erba, G. ; Lanari, M. ; Bosi, I. ; Chiriacò, P. G. ; Duse, M. ; Crispino, P. ; Soresina, M. R. ; Bresciani, E. ; Battisti, L. ; Pintor, C. ; Chiappe, F. ; Belloni, M. ; Loriano, D. ; Ibba, P. ; Berrino, R. ; Nasi, C. ; Sticca, M. ; Palmieri, M. ; Anastasio, E. ; Bezzi, T. ; Vierucci, A. ; Guarino Amato, A. ; Farina, S. ; Cecchi, M. T. ; De Maria, A. ; Fioredda, F. ; Donelli, E. ; Marazzi, M. G. ; Pontali, E. ; Forni, G. L. ; Cosso, D. ; Gotta, C. ; Lobello, D. ; Tondo, U. ; Micheletti, E. ; Ruggeri, C. ; Plebani, A. ; Pinzani, R. ; Salvini, F. ; Marchisio, P. ; Esposito, S. ; Massironi, E. ; Zuccotti, G. V. ; Riva, E. ; Gamboni, A. ; Ferraris, G. ; Rancilio, L. ; Vegni, C. ; Altobelli, R. ; Lipreri, R. ; Conio, S. ; Lizzoli, F. ; Gambaretto, G. ; Cellini, M. ; Pignata, C. ; Pozzi, N. ; Guarino, A. ; Romano, A. ; Todeschini, A. ; Giaquinto, C. ; Ruga, E. M. ; Rampon, O. ; Consolini, R. ; Palla, G. ; Legitimo, A. ; Benaglia, G. ; Caselli, D. ; Maccabruni, A. ; Pacati, I. ; Antonellini, A. ; Metri, A. ; Magnani, C. ; Falconieri, P. ; Fundarò, C. ; Genovese, O. ; Rendeli, C. ; Stegagno, M. ; Castelli Gattinara, G. ; Bernardi, S. ; Cancrini, C. ; Timpano, C. ; Anzidei, G. ; Marchili, M. R. ; Catania, S. ; Ogana, C. ; Mazza, A. ; Di Palma, A. ; Scolfaro, C. ; Riva, C. ; Palomba, E. ; Salvatore, C. / Pertussis immunization in HIV-1-infected infants : A model to assess the effects of repeated T cell-dependent antigen administrations on HIV-1 progression. Italian Register for HIV infection in children. In: Vaccine. 2000 ; Vol. 18, No. 13. pp. 1203-1209.
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abstract = "Several data evidence that HIV-1 replication may increase in temporal association with immunizations, raising concerns on potential negative effects of vaccinations on HIV-1 progression. Among patients prospectively followed by the 'Italian Register for HIV infection in children', we evaluated, using the Cox-Mantel method, conditional probabilities of progressing to CDC clinical categories 'B' or 'C', and immunological categories '2' or '3' in 88 children immunized against pertussis and 244 non- immunized. No selection criteria were followed in vaccinating children. No significant differences were observed between the two groups. The lack of a significant impact on clinical and immunological deterioration by the repeated administrations of a T cell-dependent vaccine endorses the current recommendations for routine immunizations in HIV-1-infected children.",
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TY - JOUR

T1 - Pertussis immunization in HIV-1-infected infants

T2 - A model to assess the effects of repeated T cell-dependent antigen administrations on HIV-1 progression. Italian Register for HIV infection in children

AU - Tovo, Pier Angelo

AU - de Martino, Maurizio

AU - Gabiano, Clara

AU - Galli, Luisa

AU - Osimani, P.

AU - De Mattia, D.

AU - Zizzadoro, P.

AU - Ruggeri, M.

AU - Masi, M.

AU - Dell'Erba, G.

AU - Lanari, M.

AU - Bosi, I.

AU - Chiriacò, P. G.

AU - Duse, M.

AU - Crispino, P.

AU - Soresina, M. R.

AU - Bresciani, E.

AU - Battisti, L.

AU - Pintor, C.

AU - Chiappe, F.

AU - Belloni, M.

AU - Loriano, D.

AU - Ibba, P.

AU - Berrino, R.

AU - Nasi, C.

AU - Sticca, M.

AU - Palmieri, M.

AU - Anastasio, E.

AU - Bezzi, T.

AU - Vierucci, A.

AU - Guarino Amato, A.

AU - Farina, S.

AU - Cecchi, M. T.

AU - De Maria, A.

AU - Fioredda, F.

AU - Donelli, E.

AU - Marazzi, M. G.

AU - Pontali, E.

AU - Forni, G. L.

AU - Cosso, D.

AU - Gotta, C.

AU - Lobello, D.

AU - Tondo, U.

AU - Micheletti, E.

AU - Ruggeri, C.

AU - Plebani, A.

AU - Pinzani, R.

AU - Salvini, F.

AU - Marchisio, P.

AU - Esposito, S.

AU - Massironi, E.

AU - Zuccotti, G. V.

AU - Riva, E.

AU - Gamboni, A.

AU - Ferraris, G.

AU - Rancilio, L.

AU - Vegni, C.

AU - Altobelli, R.

AU - Lipreri, R.

AU - Conio, S.

AU - Lizzoli, F.

AU - Gambaretto, G.

AU - Cellini, M.

AU - Pignata, C.

AU - Pozzi, N.

AU - Guarino, A.

AU - Romano, A.

AU - Todeschini, A.

AU - Giaquinto, C.

AU - Ruga, E. M.

AU - Rampon, O.

AU - Consolini, R.

AU - Palla, G.

AU - Legitimo, A.

AU - Benaglia, G.

AU - Caselli, D.

AU - Maccabruni, A.

AU - Pacati, I.

AU - Antonellini, A.

AU - Metri, A.

AU - Magnani, C.

AU - Falconieri, P.

AU - Fundarò, C.

AU - Genovese, O.

AU - Rendeli, C.

AU - Stegagno, M.

AU - Castelli Gattinara, G.

AU - Bernardi, S.

AU - Cancrini, C.

AU - Timpano, C.

AU - Anzidei, G.

AU - Marchili, M. R.

AU - Catania, S.

AU - Ogana, C.

AU - Mazza, A.

AU - Di Palma, A.

AU - Scolfaro, C.

AU - Riva, C.

AU - Palomba, E.

AU - Salvatore, C.

PY - 2000/1/21

Y1 - 2000/1/21

N2 - Several data evidence that HIV-1 replication may increase in temporal association with immunizations, raising concerns on potential negative effects of vaccinations on HIV-1 progression. Among patients prospectively followed by the 'Italian Register for HIV infection in children', we evaluated, using the Cox-Mantel method, conditional probabilities of progressing to CDC clinical categories 'B' or 'C', and immunological categories '2' or '3' in 88 children immunized against pertussis and 244 non- immunized. No selection criteria were followed in vaccinating children. No significant differences were observed between the two groups. The lack of a significant impact on clinical and immunological deterioration by the repeated administrations of a T cell-dependent vaccine endorses the current recommendations for routine immunizations in HIV-1-infected children.

AB - Several data evidence that HIV-1 replication may increase in temporal association with immunizations, raising concerns on potential negative effects of vaccinations on HIV-1 progression. Among patients prospectively followed by the 'Italian Register for HIV infection in children', we evaluated, using the Cox-Mantel method, conditional probabilities of progressing to CDC clinical categories 'B' or 'C', and immunological categories '2' or '3' in 88 children immunized against pertussis and 244 non- immunized. No selection criteria were followed in vaccinating children. No significant differences were observed between the two groups. The lack of a significant impact on clinical and immunological deterioration by the repeated administrations of a T cell-dependent vaccine endorses the current recommendations for routine immunizations in HIV-1-infected children.

KW - Disease progression

KW - Perinatal HIV-1 infection

KW - Pertussis immunization

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U2 - 10.1016/S0264-410X(99)00383-7

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JO - Vaccine

JF - Vaccine

SN - 0264-410X

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