Pertussis in infants and the resurgence of a vaccine preventable disease

What to do?

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

Pertussis or whooping cough remains one of the most poorly controlled vaccine-preventable diseases across the world. Universal vaccination has dramatically reduced its incidence but has failed to bring it completely under control. In the last decades, changes in pertussis epidemiology have been noted, likely related to the introduction of acellular pertussis vaccines. Increasing incidence is recorded among adolescents and adults who have become a reservoir for transmission to unimmunized infants, who are at risk of severe disease and death. In Italy, experimental evidences suggest a sustained circulation of Bordetella pertussis in the adult population and a significant health burden of pertussis among infants less than six months of age. Public health systems are currently exploring new vaccination strategies, including a cocooning strategy to prevent the transmission of the disease from family members to the newborn and vaccination of pregnant mothers to transmit protective antibodies to the offspring, and neonatal vaccination. An integrated approach for pertussis control and prevention is needed to enhance the current surveillance system and provide an accurate estimate of the real burden of pertussis in our Country, particularly among infants.

Original languageEnglish
Pages (from-to)100-103
Number of pages4
JournalAnnali dell'Istituto Superiore di Sanita
Volume53
Issue number2
DOIs
Publication statusPublished - Jan 1 2017

Fingerprint

Whooping Cough
Vaccines
Vaccination
Acellular Vaccines
Pertussis Vaccine
Bordetella pertussis
Incidence
Italy
Epidemiology
Public Health
Mothers
Newborn Infant
Antibodies
Health
Population

Keywords

  • Epidemiology
  • Pertussis
  • Vaccines

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Pertussis in infants and the resurgence of a vaccine preventable disease : What to do? / Fedele, Giorgio; Stefanelli, Paola.

In: Annali dell'Istituto Superiore di Sanita, Vol. 53, No. 2, 01.01.2017, p. 100-103.

Research output: Contribution to journalReview article

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