Pertussis toxin inhibits the antinociceptive action of morphine in the rat

Marco Parenti; Felice Tirone; Gabriella Giagnoni; Nicoletta Pecora; Daniela Parolaro

doi:10.1016/0014-2999(86)90240-2

Pertussis toxin inhibits the antinociceptive action of morphine in the rat

Marco Parenti, Felice Tirone, Gabriella Giagnoni, Nicoletta Pecora, Daniela Parolaro

Fondazione Santa Lucia

Research output: Contribution to journal › Article › peer-review

Abstract

The influence of pertussis toxin (PTX) injected intracerebroventricularly (i.c.v., 0.5 μg) on the analgesic effect induced in the rat by i.c.v. injection of morphine (5 μg) was studied. Morphine analgesia was unaffected 24 h after toxin administration, but there was a significant decrease after 6 days. Therefore a PTX-sensitive substrate, probably a guanine nucleotide regulatory protein could be involved in the coupling of opiate receptors to cellular effectors responsible for the expression of the antinociceptive action of morphine.

Original language	English
Pages (from-to)	357-359
Number of pages	3
Journal	European Journal of Pharmacology
Volume	124
Issue number	3
DOIs	https://doi.org/10.1016/0014-2999(86)90240-2
Publication status	Published - May 27 1986

Keywords

Adenylate cyclase
Analgesia
Morphine
Pertussis toxin

ASJC Scopus subject areas

Cellular and Molecular Neuroscience
Pharmacology

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10.1016/0014-2999(86)90240-2

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title = "Pertussis toxin inhibits the antinociceptive action of morphine in the rat",

abstract = "The influence of pertussis toxin (PTX) injected intracerebroventricularly (i.c.v., 0.5 μg) on the analgesic effect induced in the rat by i.c.v. injection of morphine (5 μg) was studied. Morphine analgesia was unaffected 24 h after toxin administration, but there was a significant decrease after 6 days. Therefore a PTX-sensitive substrate, probably a guanine nucleotide regulatory protein could be involved in the coupling of opiate receptors to cellular effectors responsible for the expression of the antinociceptive action of morphine.",

keywords = "Adenylate cyclase, Analgesia, Morphine, Pertussis toxin",

author = "Marco Parenti and Felice Tirone and Gabriella Giagnoni and Nicoletta Pecora and Daniela Parolaro",

year = "1986",

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T1 - Pertussis toxin inhibits the antinociceptive action of morphine in the rat

AU - Parenti, Marco

AU - Tirone, Felice

AU - Giagnoni, Gabriella

AU - Pecora, Nicoletta

AU - Parolaro, Daniela

PY - 1986/5/27

Y1 - 1986/5/27

N2 - The influence of pertussis toxin (PTX) injected intracerebroventricularly (i.c.v., 0.5 μg) on the analgesic effect induced in the rat by i.c.v. injection of morphine (5 μg) was studied. Morphine analgesia was unaffected 24 h after toxin administration, but there was a significant decrease after 6 days. Therefore a PTX-sensitive substrate, probably a guanine nucleotide regulatory protein could be involved in the coupling of opiate receptors to cellular effectors responsible for the expression of the antinociceptive action of morphine.

AB - The influence of pertussis toxin (PTX) injected intracerebroventricularly (i.c.v., 0.5 μg) on the analgesic effect induced in the rat by i.c.v. injection of morphine (5 μg) was studied. Morphine analgesia was unaffected 24 h after toxin administration, but there was a significant decrease after 6 days. Therefore a PTX-sensitive substrate, probably a guanine nucleotide regulatory protein could be involved in the coupling of opiate receptors to cellular effectors responsible for the expression of the antinociceptive action of morphine.

KW - Adenylate cyclase

KW - Analgesia

KW - Morphine

KW - Pertussis toxin

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