Pertussis toxin inhibits the antinociceptive action of morphine in the rat

Marco Parenti, Felice Tirone, Gabriella Giagnoni, Nicoletta Pecora, Daniela Parolaro

Research output: Contribution to journalArticlepeer-review

Abstract

The influence of pertussis toxin (PTX) injected intracerebroventricularly (i.c.v., 0.5 μg) on the analgesic effect induced in the rat by i.c.v. injection of morphine (5 μg) was studied. Morphine analgesia was unaffected 24 h after toxin administration, but there was a significant decrease after 6 days. Therefore a PTX-sensitive substrate, probably a guanine nucleotide regulatory protein could be involved in the coupling of opiate receptors to cellular effectors responsible for the expression of the antinociceptive action of morphine.

Original languageEnglish
Pages (from-to)357-359
Number of pages3
JournalEuropean Journal of Pharmacology
Volume124
Issue number3
DOIs
Publication statusPublished - May 27 1986

Keywords

  • Adenylate cyclase
  • Analgesia
  • Morphine
  • Pertussis toxin

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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