Abstract
The influence of pertussis toxin (PTX) injected intracerebroventricularly (i.c.v., 0.5 μg) on the analgesic effect induced in the rat by i.c.v. injection of morphine (5 μg) was studied. Morphine analgesia was unaffected 24 h after toxin administration, but there was a significant decrease after 6 days. Therefore a PTX-sensitive substrate, probably a guanine nucleotide regulatory protein could be involved in the coupling of opiate receptors to cellular effectors responsible for the expression of the antinociceptive action of morphine.
| Original language | English |
|---|---|
| Pages (from-to) | 357-359 |
| Number of pages | 3 |
| Journal | European Journal of Pharmacology |
| Volume | 124 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - May 27 1986 |
Fingerprint
Keywords
- Adenylate cyclase
- Analgesia
- Morphine
- Pertussis toxin
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience
- Pharmacology
Cite this
Pertussis toxin inhibits the antinociceptive action of morphine in the rat. / Parenti, Marco; Tirone, Felice; Giagnoni, Gabriella; Pecora, Nicoletta; Parolaro, Daniela.
In: European Journal of Pharmacology, Vol. 124, No. 3, 27.05.1986, p. 357-359.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pertussis toxin inhibits the antinociceptive action of morphine in the rat
AU - Parenti, Marco
AU - Tirone, Felice
AU - Giagnoni, Gabriella
AU - Pecora, Nicoletta
AU - Parolaro, Daniela
PY - 1986/5/27
Y1 - 1986/5/27
N2 - The influence of pertussis toxin (PTX) injected intracerebroventricularly (i.c.v., 0.5 μg) on the analgesic effect induced in the rat by i.c.v. injection of morphine (5 μg) was studied. Morphine analgesia was unaffected 24 h after toxin administration, but there was a significant decrease after 6 days. Therefore a PTX-sensitive substrate, probably a guanine nucleotide regulatory protein could be involved in the coupling of opiate receptors to cellular effectors responsible for the expression of the antinociceptive action of morphine.
AB - The influence of pertussis toxin (PTX) injected intracerebroventricularly (i.c.v., 0.5 μg) on the analgesic effect induced in the rat by i.c.v. injection of morphine (5 μg) was studied. Morphine analgesia was unaffected 24 h after toxin administration, but there was a significant decrease after 6 days. Therefore a PTX-sensitive substrate, probably a guanine nucleotide regulatory protein could be involved in the coupling of opiate receptors to cellular effectors responsible for the expression of the antinociceptive action of morphine.
KW - Adenylate cyclase
KW - Analgesia
KW - Morphine
KW - Pertussis toxin
UR - http://www.scopus.com/inward/record.url?scp=0022611660&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022611660&partnerID=8YFLogxK
U2 - 10.1016/0014-2999(86)90240-2
DO - 10.1016/0014-2999(86)90240-2
M3 - Article
C2 - 3732384
AN - SCOPUS:0022611660
VL - 124
SP - 357
EP - 359
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
IS - 3
ER -