PET guidance in prostate cancer radiotherapy

Quantitative imaging to predict response and guide treatment

G. M. Cattaneo, V. Bettinardi, P. Mapelli, M. Picchio

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Positron emission tomography (PET) allows a monitoring and recording of the spatial and temporal distribution of molecular/cellular processes for diagnostic and therapeutic applications.The aim of this review is to describe the current applications and to explore the role of PET in prostate cancer management, mainly in the radiation therapy (RT) scenario.The state-of-the art of PET for prostate cancer will be presented together with the impact of new specific PET tracers and technological developments aiming at obtaining better imaging quality, increased tumor detectability and more accurate volume delineation.An increased number of studies have been focusing on PET quantification methods as predictive biomarkers capable of guiding individualized treatment and improving patient outcome; the sophisticated advanced intensity modulated and imaged guided radiation therapy techniques (IMRT/IGRT) are capable of boosting more radioresistant tumor (sub)volumes.The use of advanced feature analyses of PET images is an approach that holds great promise with regard to several oncological diseases, but needs further validation in managing prostate diseases.

Original languageEnglish
Pages (from-to)452-458
Number of pages7
JournalPhysica Medica
Volume32
Issue number3
DOIs
Publication statusPublished - Mar 1 2016

Fingerprint

Positron-Emission Tomography
radiation therapy
positrons
Prostatic Neoplasms
Radiotherapy
tomography
cancer
Therapeutics
tumors
temporal distribution
delineation
biomarkers
Tumor Burden
tracers
Prostate
spatial distribution
Biomarkers
recording
Neoplasms

Keywords

  • Individualized treatment
  • Pet
  • Predicting biomarkers
  • Prostate cancer

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging
  • Physics and Astronomy(all)

Cite this

PET guidance in prostate cancer radiotherapy : Quantitative imaging to predict response and guide treatment. / Cattaneo, G. M.; Bettinardi, V.; Mapelli, P.; Picchio, M.

In: Physica Medica, Vol. 32, No. 3, 01.03.2016, p. 452-458.

Research output: Contribution to journalArticle

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