PET/CT assessment of neuroendocrine tumors of the lung with special emphasis on bronchial carcinoids

Filippo Lococo, Alfredo Cesario, Massimiliano Paci, Angelina Filice, Annibale Versari, Cristian Rapicetta, Tommaso Ricchetti, Giorgio Sgarbi, Marco Alifano, Alberto Cavazza, Giorgio Treglia

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Pulmonary neuroendocrine tumors (pNETs) arise from bronchial mucosal cells known as enterochromaffin cells which are part of the diffuse neuroendocrine system. The pathological spectrum of pNETs ranges from low-/intermediate-grade neoplasms such as bronchial carcinoids (BCs), also known as typical or atypical carcinoids, to high-grade neoplasms as large-cell neuroendocrine carcinoma and small-cell lung cancer. The tumor biology of pNETs still represents a matter of open debate. The distinct features among the different pNETs include not only their pathologic characteristics but also their clinical behavior, epidemiology, treatment, and prognosis. In this sense, a correct pathological identification in the preoperative setting is a key element for planning the best strategy of care in pNETs and especially in BCs. Controversial results have been reported on the diagnostic accuracy of fluorine-18-fluorodeoxyglucose positron emission tomography or positron emission tomography/computed tomography (F-18-FDG PET or PET/CT) in BCs. On the other hand, there is increasing evidence supporting the use of PET with somatostatin analogues (DOTA-TOC, DOTA-NOC, or DOTA-TATE) labeled with gallium-68 (Ga-68) in pNETs. Herein, we review the pertinent literature aiming to better define the current state of art of PET/CT in the detection and histological differentiation of pNETs with special emphasis on BCs.

Original languageEnglish
Pages (from-to)8369-8377
Number of pages9
JournalTumor Biology
Volume35
Issue number9
DOIs
Publication statusPublished - Oct 9 2014

Fingerprint

Neuroendocrine Tumors
Carcinoid Tumor
Lung
Enterochromaffin Cells
Neuroendocrine Carcinoma
Large Cell Carcinoma
Neoplasms
Neurosecretory Systems
Gallium
Fluorodeoxyglucose F18
Small Cell Lung Carcinoma
Somatostatin
Positron-Emission Tomography
Epidemiology

Keywords

  • Functional imaging
  • Neuroendocrine tumors
  • PET/CT
  • Pulmonary tumors

ASJC Scopus subject areas

  • Cancer Research
  • Medicine(all)

Cite this

PET/CT assessment of neuroendocrine tumors of the lung with special emphasis on bronchial carcinoids. / Lococo, Filippo; Cesario, Alfredo; Paci, Massimiliano; Filice, Angelina; Versari, Annibale; Rapicetta, Cristian; Ricchetti, Tommaso; Sgarbi, Giorgio; Alifano, Marco; Cavazza, Alberto; Treglia, Giorgio.

In: Tumor Biology, Vol. 35, No. 9, 09.10.2014, p. 8369-8377.

Research output: Contribution to journalArticle

@article{a3d1fa66dfa142939dd59b0cfe2728be,
title = "PET/CT assessment of neuroendocrine tumors of the lung with special emphasis on bronchial carcinoids",
abstract = "Pulmonary neuroendocrine tumors (pNETs) arise from bronchial mucosal cells known as enterochromaffin cells which are part of the diffuse neuroendocrine system. The pathological spectrum of pNETs ranges from low-/intermediate-grade neoplasms such as bronchial carcinoids (BCs), also known as typical or atypical carcinoids, to high-grade neoplasms as large-cell neuroendocrine carcinoma and small-cell lung cancer. The tumor biology of pNETs still represents a matter of open debate. The distinct features among the different pNETs include not only their pathologic characteristics but also their clinical behavior, epidemiology, treatment, and prognosis. In this sense, a correct pathological identification in the preoperative setting is a key element for planning the best strategy of care in pNETs and especially in BCs. Controversial results have been reported on the diagnostic accuracy of fluorine-18-fluorodeoxyglucose positron emission tomography or positron emission tomography/computed tomography (F-18-FDG PET or PET/CT) in BCs. On the other hand, there is increasing evidence supporting the use of PET with somatostatin analogues (DOTA-TOC, DOTA-NOC, or DOTA-TATE) labeled with gallium-68 (Ga-68) in pNETs. Herein, we review the pertinent literature aiming to better define the current state of art of PET/CT in the detection and histological differentiation of pNETs with special emphasis on BCs.",
keywords = "Functional imaging, Neuroendocrine tumors, PET/CT, Pulmonary tumors",
author = "Filippo Lococo and Alfredo Cesario and Massimiliano Paci and Angelina Filice and Annibale Versari and Cristian Rapicetta and Tommaso Ricchetti and Giorgio Sgarbi and Marco Alifano and Alberto Cavazza and Giorgio Treglia",
year = "2014",
month = "10",
day = "9",
doi = "10.1007/s13277-014-2102-y",
language = "English",
volume = "35",
pages = "8369--8377",
journal = "Tumor Biology",
issn = "1010-4283",
publisher = "Springer Netherlands",
number = "9",

}

TY - JOUR

T1 - PET/CT assessment of neuroendocrine tumors of the lung with special emphasis on bronchial carcinoids

AU - Lococo, Filippo

AU - Cesario, Alfredo

AU - Paci, Massimiliano

AU - Filice, Angelina

AU - Versari, Annibale

AU - Rapicetta, Cristian

AU - Ricchetti, Tommaso

AU - Sgarbi, Giorgio

AU - Alifano, Marco

AU - Cavazza, Alberto

AU - Treglia, Giorgio

PY - 2014/10/9

Y1 - 2014/10/9

N2 - Pulmonary neuroendocrine tumors (pNETs) arise from bronchial mucosal cells known as enterochromaffin cells which are part of the diffuse neuroendocrine system. The pathological spectrum of pNETs ranges from low-/intermediate-grade neoplasms such as bronchial carcinoids (BCs), also known as typical or atypical carcinoids, to high-grade neoplasms as large-cell neuroendocrine carcinoma and small-cell lung cancer. The tumor biology of pNETs still represents a matter of open debate. The distinct features among the different pNETs include not only their pathologic characteristics but also their clinical behavior, epidemiology, treatment, and prognosis. In this sense, a correct pathological identification in the preoperative setting is a key element for planning the best strategy of care in pNETs and especially in BCs. Controversial results have been reported on the diagnostic accuracy of fluorine-18-fluorodeoxyglucose positron emission tomography or positron emission tomography/computed tomography (F-18-FDG PET or PET/CT) in BCs. On the other hand, there is increasing evidence supporting the use of PET with somatostatin analogues (DOTA-TOC, DOTA-NOC, or DOTA-TATE) labeled with gallium-68 (Ga-68) in pNETs. Herein, we review the pertinent literature aiming to better define the current state of art of PET/CT in the detection and histological differentiation of pNETs with special emphasis on BCs.

AB - Pulmonary neuroendocrine tumors (pNETs) arise from bronchial mucosal cells known as enterochromaffin cells which are part of the diffuse neuroendocrine system. The pathological spectrum of pNETs ranges from low-/intermediate-grade neoplasms such as bronchial carcinoids (BCs), also known as typical or atypical carcinoids, to high-grade neoplasms as large-cell neuroendocrine carcinoma and small-cell lung cancer. The tumor biology of pNETs still represents a matter of open debate. The distinct features among the different pNETs include not only their pathologic characteristics but also their clinical behavior, epidemiology, treatment, and prognosis. In this sense, a correct pathological identification in the preoperative setting is a key element for planning the best strategy of care in pNETs and especially in BCs. Controversial results have been reported on the diagnostic accuracy of fluorine-18-fluorodeoxyglucose positron emission tomography or positron emission tomography/computed tomography (F-18-FDG PET or PET/CT) in BCs. On the other hand, there is increasing evidence supporting the use of PET with somatostatin analogues (DOTA-TOC, DOTA-NOC, or DOTA-TATE) labeled with gallium-68 (Ga-68) in pNETs. Herein, we review the pertinent literature aiming to better define the current state of art of PET/CT in the detection and histological differentiation of pNETs with special emphasis on BCs.

KW - Functional imaging

KW - Neuroendocrine tumors

KW - PET/CT

KW - Pulmonary tumors

UR - http://www.scopus.com/inward/record.url?scp=84919843331&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84919843331&partnerID=8YFLogxK

U2 - 10.1007/s13277-014-2102-y

DO - 10.1007/s13277-014-2102-y

M3 - Article

C2 - 24850179

AN - SCOPUS:84919843331

VL - 35

SP - 8369

EP - 8377

JO - Tumor Biology

JF - Tumor Biology

SN - 1010-4283

IS - 9

ER -