PET/CT imaging in mouse models of myocardial ischemia

Sara Gargiulo, Adelaide Greco, Matteo Gramanzini, Maria Piera Petretta, Adele Ferro, Michele Larobina, Mariarosaria Panico, Arturo Brunetti, Alberto Cuocolo

Research output: Contribution to journalArticle

Abstract

Different species have been used to reproduce myocardial infarction models but in the last years mice became the animals of choice for the analysis of several diseases, due to their short life cycle and the possibility of genetic manipulation. Many techniques are currently used for cardiovascular imaging in mice, including X-ray computed tomography (CT), high-resolution ultrasound, magnetic resonance imaging, and nuclear medicine procedures. Cardiac positron emission tomography (PET) allows to examine noninvasively, on a molecular level and with high sensitivity, regional changes in myocardial perfusion, metabolism, apoptosis, inflammation, and gene expression or to measure changes in anatomical and functional parameters in heart diseases. Currently hybrid PET/CT scanners for small laboratory animals are available, where CT adds high-resolution anatomical information. This paper reviews mouse models of myocardial infarction and discusses the applications of dedicated PET/CT systems technology, including animal preparation, anesthesia, radiotracers, and images postprocessing.

Original languageEnglish
Article number541872
JournalJournal of Biomedicine and Biotechnology
Volume2012
DOIs
Publication statusPublished - 2012

Fingerprint

Myocardial Ischemia
Myocardial Infarction
X-Ray Computed Tomography Scanners
X Ray Computed Tomography
Nuclear Medicine
Laboratory Animals
Life Cycle Stages
Positron-Emission Tomography
Heart Diseases
Anesthesia
Perfusion
Tomography
Magnetic Resonance Imaging
Apoptosis
Inflammation
Technology
Gene Expression
Positron Emission Tomography Computed Tomography

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Medicine
  • Genetics
  • Molecular Biology
  • Health, Toxicology and Mutagenesis
  • Medicine(all)

Cite this

Gargiulo, S., Greco, A., Gramanzini, M., Petretta, M. P., Ferro, A., Larobina, M., ... Cuocolo, A. (2012). PET/CT imaging in mouse models of myocardial ischemia. Journal of Biomedicine and Biotechnology, 2012, [541872]. https://doi.org/10.1155/2012/541872

PET/CT imaging in mouse models of myocardial ischemia. / Gargiulo, Sara; Greco, Adelaide; Gramanzini, Matteo; Petretta, Maria Piera; Ferro, Adele; Larobina, Michele; Panico, Mariarosaria; Brunetti, Arturo; Cuocolo, Alberto.

In: Journal of Biomedicine and Biotechnology, Vol. 2012, 541872, 2012.

Research output: Contribution to journalArticle

Gargiulo, S, Greco, A, Gramanzini, M, Petretta, MP, Ferro, A, Larobina, M, Panico, M, Brunetti, A & Cuocolo, A 2012, 'PET/CT imaging in mouse models of myocardial ischemia', Journal of Biomedicine and Biotechnology, vol. 2012, 541872. https://doi.org/10.1155/2012/541872
Gargiulo S, Greco A, Gramanzini M, Petretta MP, Ferro A, Larobina M et al. PET/CT imaging in mouse models of myocardial ischemia. Journal of Biomedicine and Biotechnology. 2012;2012. 541872. https://doi.org/10.1155/2012/541872
Gargiulo, Sara ; Greco, Adelaide ; Gramanzini, Matteo ; Petretta, Maria Piera ; Ferro, Adele ; Larobina, Michele ; Panico, Mariarosaria ; Brunetti, Arturo ; Cuocolo, Alberto. / PET/CT imaging in mouse models of myocardial ischemia. In: Journal of Biomedicine and Biotechnology. 2012 ; Vol. 2012.
@article{583cc8f604ee4c9d8d6fadc788e55c2d,
title = "PET/CT imaging in mouse models of myocardial ischemia",
abstract = "Different species have been used to reproduce myocardial infarction models but in the last years mice became the animals of choice for the analysis of several diseases, due to their short life cycle and the possibility of genetic manipulation. Many techniques are currently used for cardiovascular imaging in mice, including X-ray computed tomography (CT), high-resolution ultrasound, magnetic resonance imaging, and nuclear medicine procedures. Cardiac positron emission tomography (PET) allows to examine noninvasively, on a molecular level and with high sensitivity, regional changes in myocardial perfusion, metabolism, apoptosis, inflammation, and gene expression or to measure changes in anatomical and functional parameters in heart diseases. Currently hybrid PET/CT scanners for small laboratory animals are available, where CT adds high-resolution anatomical information. This paper reviews mouse models of myocardial infarction and discusses the applications of dedicated PET/CT systems technology, including animal preparation, anesthesia, radiotracers, and images postprocessing.",
author = "Sara Gargiulo and Adelaide Greco and Matteo Gramanzini and Petretta, {Maria Piera} and Adele Ferro and Michele Larobina and Mariarosaria Panico and Arturo Brunetti and Alberto Cuocolo",
year = "2012",
doi = "10.1155/2012/541872",
language = "English",
volume = "2012",
journal = "Journal of Biomedicine and Biotechnology",
issn = "1110-7243",
publisher = "Hindawi Publishing Corporation",

}

TY - JOUR

T1 - PET/CT imaging in mouse models of myocardial ischemia

AU - Gargiulo, Sara

AU - Greco, Adelaide

AU - Gramanzini, Matteo

AU - Petretta, Maria Piera

AU - Ferro, Adele

AU - Larobina, Michele

AU - Panico, Mariarosaria

AU - Brunetti, Arturo

AU - Cuocolo, Alberto

PY - 2012

Y1 - 2012

N2 - Different species have been used to reproduce myocardial infarction models but in the last years mice became the animals of choice for the analysis of several diseases, due to their short life cycle and the possibility of genetic manipulation. Many techniques are currently used for cardiovascular imaging in mice, including X-ray computed tomography (CT), high-resolution ultrasound, magnetic resonance imaging, and nuclear medicine procedures. Cardiac positron emission tomography (PET) allows to examine noninvasively, on a molecular level and with high sensitivity, regional changes in myocardial perfusion, metabolism, apoptosis, inflammation, and gene expression or to measure changes in anatomical and functional parameters in heart diseases. Currently hybrid PET/CT scanners for small laboratory animals are available, where CT adds high-resolution anatomical information. This paper reviews mouse models of myocardial infarction and discusses the applications of dedicated PET/CT systems technology, including animal preparation, anesthesia, radiotracers, and images postprocessing.

AB - Different species have been used to reproduce myocardial infarction models but in the last years mice became the animals of choice for the analysis of several diseases, due to their short life cycle and the possibility of genetic manipulation. Many techniques are currently used for cardiovascular imaging in mice, including X-ray computed tomography (CT), high-resolution ultrasound, magnetic resonance imaging, and nuclear medicine procedures. Cardiac positron emission tomography (PET) allows to examine noninvasively, on a molecular level and with high sensitivity, regional changes in myocardial perfusion, metabolism, apoptosis, inflammation, and gene expression or to measure changes in anatomical and functional parameters in heart diseases. Currently hybrid PET/CT scanners for small laboratory animals are available, where CT adds high-resolution anatomical information. This paper reviews mouse models of myocardial infarction and discusses the applications of dedicated PET/CT systems technology, including animal preparation, anesthesia, radiotracers, and images postprocessing.

UR - http://www.scopus.com/inward/record.url?scp=84859713581&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84859713581&partnerID=8YFLogxK

U2 - 10.1155/2012/541872

DO - 10.1155/2012/541872

M3 - Article

C2 - 22505813

AN - SCOPUS:84859713581

VL - 2012

JO - Journal of Biomedicine and Biotechnology

JF - Journal of Biomedicine and Biotechnology

SN - 1110-7243

M1 - 541872

ER -