Peyronie's disease and autoimmunity-a real-life clinical study and comprehensive review

Eugenio Ventimiglia; Paolo Capogrosso; Michele Colicchia; Luca Boeri; Alessandro Serino; Giovanni La Croce; Andrea Russo; Umberto Capitanio; Alberto Briganti; Francesco Cantiello; Vincenzo Mirone; Rocco Damiano; Francesco Montorsi; Andrea Salonia

doi:10.1111/jsm.12825

Peyronie's disease and autoimmunity-a real-life clinical study and comprehensive review

Eugenio Ventimiglia, Paolo Capogrosso, Michele Colicchia, Luca Boeri, Alessandro Serino, Giovanni La Croce, Andrea Russo, Umberto Capitanio, Alberto Briganti, Francesco Cantiello, Vincenzo Mirone, Rocco Damiano, Francesco Montorsi, Andrea Salonia

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

Introduction: Although heavily investigated over the last decades, Peyronie's disease (PD) pathogenesis remains unclear. Aim: We sought to investigate the association between PD and autoimmune diseases (ADs) in men seeking medical help for sexual dysfunction in the real-life setting. Methods: Complete sociodemographic and clinical data from a homogenous cohort of 1,140 consecutive Caucasian-European men were analyzed. Health-significant comorbidities were scored with the Charlson Comorbidity Index and ADs were stratified according to International Classification of Diseases, Ninth Revision classification. Main Outcome Measures: Descriptive statistics and multivariate logistic regression models tested the association between ADs and PD. Results: PD was diagnosed in 148 (13%) of the 1,140 men; of PD patients, 14 (9.5%) had a comorbid AD; conversely, the rate of ADs in non-PD patients was significantly lower (χ²=24.7; P

Original language	English
Pages (from-to)	1062-1069
Number of pages	8
Journal	Journal of Sexual Medicine
Volume	12
Issue number	4
DOIs	https://doi.org/10.1111/jsm.12825
Publication status	Published - Apr 1 2015

Keywords

Autoimmune Disease
Peyronie's Disease
Psoriasis
Sexual Dysfunction

ASJC Scopus subject areas

Urology
Obstetrics and Gynaecology
Reproductive Medicine
Medicine(all)

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10.1111/jsm.12825

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title = "Peyronie's disease and autoimmunity-a real-life clinical study and comprehensive review",

abstract = "Introduction: Although heavily investigated over the last decades, Peyronie's disease (PD) pathogenesis remains unclear. Aim: We sought to investigate the association between PD and autoimmune diseases (ADs) in men seeking medical help for sexual dysfunction in the real-life setting. Methods: Complete sociodemographic and clinical data from a homogenous cohort of 1,140 consecutive Caucasian-European men were analyzed. Health-significant comorbidities were scored with the Charlson Comorbidity Index and ADs were stratified according to International Classification of Diseases, Ninth Revision classification. Main Outcome Measures: Descriptive statistics and multivariate logistic regression models tested the association between ADs and PD. Results: PD was diagnosed in 148 (13%) of the 1,140 men; of PD patients, 14 (9.5%) had a comorbid AD; conversely, the rate of ADs in non-PD patients was significantly lower (χ2=24.7; P",

keywords = "Autoimmune Disease, Peyronie's Disease, Psoriasis, Sexual Dysfunction",

author = "Eugenio Ventimiglia and Paolo Capogrosso and Michele Colicchia and Luca Boeri and Alessandro Serino and {La Croce}, Giovanni and Andrea Russo and Umberto Capitanio and Alberto Briganti and Francesco Cantiello and Vincenzo Mirone and Rocco Damiano and Francesco Montorsi and Andrea Salonia",

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doi = "10.1111/jsm.12825",

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AU - Ventimiglia, Eugenio

AU - Capogrosso, Paolo

AU - Colicchia, Michele

AU - Boeri, Luca

AU - Serino, Alessandro

AU - La Croce, Giovanni

AU - Russo, Andrea

AU - Capitanio, Umberto

AU - Briganti, Alberto

AU - Cantiello, Francesco

AU - Mirone, Vincenzo

AU - Damiano, Rocco

AU - Montorsi, Francesco

AU - Salonia, Andrea

PY - 2015/4/1

Y1 - 2015/4/1

N2 - Introduction: Although heavily investigated over the last decades, Peyronie's disease (PD) pathogenesis remains unclear. Aim: We sought to investigate the association between PD and autoimmune diseases (ADs) in men seeking medical help for sexual dysfunction in the real-life setting. Methods: Complete sociodemographic and clinical data from a homogenous cohort of 1,140 consecutive Caucasian-European men were analyzed. Health-significant comorbidities were scored with the Charlson Comorbidity Index and ADs were stratified according to International Classification of Diseases, Ninth Revision classification. Main Outcome Measures: Descriptive statistics and multivariate logistic regression models tested the association between ADs and PD. Results: PD was diagnosed in 148 (13%) of the 1,140 men; of PD patients, 14 (9.5%) had a comorbid AD; conversely, the rate of ADs in non-PD patients was significantly lower (χ2=24.7; P

AB - Introduction: Although heavily investigated over the last decades, Peyronie's disease (PD) pathogenesis remains unclear. Aim: We sought to investigate the association between PD and autoimmune diseases (ADs) in men seeking medical help for sexual dysfunction in the real-life setting. Methods: Complete sociodemographic and clinical data from a homogenous cohort of 1,140 consecutive Caucasian-European men were analyzed. Health-significant comorbidities were scored with the Charlson Comorbidity Index and ADs were stratified according to International Classification of Diseases, Ninth Revision classification. Main Outcome Measures: Descriptive statistics and multivariate logistic regression models tested the association between ADs and PD. Results: PD was diagnosed in 148 (13%) of the 1,140 men; of PD patients, 14 (9.5%) had a comorbid AD; conversely, the rate of ADs in non-PD patients was significantly lower (χ2=24.7; P

KW - Autoimmune Disease

KW - Peyronie's Disease

KW - Psoriasis

KW - Sexual Dysfunction

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Peyronie's disease and autoimmunity-a real-life clinical study and comprehensive review

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Keywords

ASJC Scopus subject areas

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