Peyronie's disease and autoimmunity-a real-life clinical study and comprehensive review

Eugenio Ventimiglia, Paolo Capogrosso, Michele Colicchia, Luca Boeri, Alessandro Serino, Giovanni La Croce, Andrea Russo, Umberto Capitanio, Alberto Briganti, Francesco Cantiello, Vincenzo Mirone, Rocco Damiano, Francesco Montorsi, Andrea Salonia

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: Although heavily investigated over the last decades, Peyronie's disease (PD) pathogenesis remains unclear. Aim: We sought to investigate the association between PD and autoimmune diseases (ADs) in men seeking medical help for sexual dysfunction in the real-life setting. Methods: Complete sociodemographic and clinical data from a homogenous cohort of 1,140 consecutive Caucasian-European men were analyzed. Health-significant comorbidities were scored with the Charlson Comorbidity Index and ADs were stratified according to International Classification of Diseases, Ninth Revision classification. Main Outcome Measures: Descriptive statistics and multivariate logistic regression models tested the association between ADs and PD. Results: PD was diagnosed in 148 (13%) of the 1,140 men; of PD patients, 14 (9.5%) had a comorbid AD; conversely, the rate of ADs in non-PD patients was significantly lower (χ2=24.7; P

Original languageEnglish
Pages (from-to)1062-1069
Number of pages8
JournalJournal of Sexual Medicine
Volume12
Issue number4
DOIs
Publication statusPublished - Apr 1 2015

Keywords

  • Autoimmune Disease
  • Peyronie's Disease
  • Psoriasis
  • Sexual Dysfunction

ASJC Scopus subject areas

  • Urology
  • Obstetrics and Gynaecology
  • Reproductive Medicine
  • Medicine(all)

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