Abstract
Background: The addition of impedance to 24-h pH monitoring has allowed detection of weakly acidic reflux, but the extent to which pH-impedance (pH-MII) monitoring improves outcomes is unknown. Methods: This was a prospective observational study. Patients referred for pH or pH-MII monitoring completed a standardized questionnaire on improvement in the dominant symptom, their satisfaction, and treatment at 3 and 12 months after the test during a telephone interview. Results: A total of 184 patients (mean age, 52 years, range, 19–82 years; 35 % with typical symptoms; and 89 % tested off therapy) completed pH (n = 92) or pH-MII monitoring (n = 92) over a period of 15 months. The two arms were similar in terms of demographic, clinical, and endoscopic variables. Ten patients in the pH-MII arm showed evidence of weakly acidic reflux disease. There was no difference in the percentage of patients in the pH and pH-MII monitoring arms who experienced improvement in their dominant symptom after 3 (58 vs. 63 %; p = 0.621) or 12 months (66 vs. 70 %; p = 0.234), and the same was true for patient satisfaction. There were also no between-group difference in the use of proton pump inhibitors (PPIs) after 3 (63 vs. 68.5 %; p = 0.437) or 12 months (47 vs. 60.5 %; p = 0.051). PPIs were prescribed more frequently after a positive test (p
| Original language | English |
|---|---|
| Pages (from-to) | 130-137 |
| Number of pages | 8 |
| Journal | Journal of Gastroenterology |
| Volume | 51 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 1 2016 |
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Keywords
- Gastroesophageal reflux
- Impedance-pH monitoring
- Patient’s outcome
ASJC Scopus subject areas
- Gastroenterology
Cite this
pH Impedance vs. traditional pH monitoring in clinical practice : an outcome study. / Pugliese, Delia; Mauro, Aurelio; Consonni, Dario; Bravi, Ivana; Tenca, Andrea; Elvevi, Alessandra; Conte, Dario; Penagini, Roberto.
In: Journal of Gastroenterology, Vol. 51, No. 2, 01.02.2016, p. 130-137.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - pH Impedance vs. traditional pH monitoring in clinical practice
T2 - an outcome study
AU - Pugliese, Delia
AU - Mauro, Aurelio
AU - Consonni, Dario
AU - Bravi, Ivana
AU - Tenca, Andrea
AU - Elvevi, Alessandra
AU - Conte, Dario
AU - Penagini, Roberto
PY - 2016/2/1
Y1 - 2016/2/1
N2 - Background: The addition of impedance to 24-h pH monitoring has allowed detection of weakly acidic reflux, but the extent to which pH-impedance (pH-MII) monitoring improves outcomes is unknown. Methods: This was a prospective observational study. Patients referred for pH or pH-MII monitoring completed a standardized questionnaire on improvement in the dominant symptom, their satisfaction, and treatment at 3 and 12 months after the test during a telephone interview. Results: A total of 184 patients (mean age, 52 years, range, 19–82 years; 35 % with typical symptoms; and 89 % tested off therapy) completed pH (n = 92) or pH-MII monitoring (n = 92) over a period of 15 months. The two arms were similar in terms of demographic, clinical, and endoscopic variables. Ten patients in the pH-MII arm showed evidence of weakly acidic reflux disease. There was no difference in the percentage of patients in the pH and pH-MII monitoring arms who experienced improvement in their dominant symptom after 3 (58 vs. 63 %; p = 0.621) or 12 months (66 vs. 70 %; p = 0.234), and the same was true for patient satisfaction. There were also no between-group difference in the use of proton pump inhibitors (PPIs) after 3 (63 vs. 68.5 %; p = 0.437) or 12 months (47 vs. 60.5 %; p = 0.051). PPIs were prescribed more frequently after a positive test (p
AB - Background: The addition of impedance to 24-h pH monitoring has allowed detection of weakly acidic reflux, but the extent to which pH-impedance (pH-MII) monitoring improves outcomes is unknown. Methods: This was a prospective observational study. Patients referred for pH or pH-MII monitoring completed a standardized questionnaire on improvement in the dominant symptom, their satisfaction, and treatment at 3 and 12 months after the test during a telephone interview. Results: A total of 184 patients (mean age, 52 years, range, 19–82 years; 35 % with typical symptoms; and 89 % tested off therapy) completed pH (n = 92) or pH-MII monitoring (n = 92) over a period of 15 months. The two arms were similar in terms of demographic, clinical, and endoscopic variables. Ten patients in the pH-MII arm showed evidence of weakly acidic reflux disease. There was no difference in the percentage of patients in the pH and pH-MII monitoring arms who experienced improvement in their dominant symptom after 3 (58 vs. 63 %; p = 0.621) or 12 months (66 vs. 70 %; p = 0.234), and the same was true for patient satisfaction. There were also no between-group difference in the use of proton pump inhibitors (PPIs) after 3 (63 vs. 68.5 %; p = 0.437) or 12 months (47 vs. 60.5 %; p = 0.051). PPIs were prescribed more frequently after a positive test (p
KW - Gastroesophageal reflux
KW - Impedance-pH monitoring
KW - Patient’s outcome
UR - http://www.scopus.com/inward/record.url?scp=84957438941&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84957438941&partnerID=8YFLogxK
U2 - 10.1007/s00535-015-1090-z
DO - 10.1007/s00535-015-1090-z
M3 - Article
AN - SCOPUS:84957438941
VL - 51
SP - 130
EP - 137
JO - Journal of Gastroenterology
JF - Journal of Gastroenterology
SN - 0944-1174
IS - 2
ER -