pH Impedance vs. traditional pH monitoring in clinical practice: an outcome study

Delia Pugliese, Aurelio Mauro, Dario Consonni, Ivana Bravi, Andrea Tenca, Alessandra Elvevi, Dario Conte, Roberto Penagini

Research output: Contribution to journalArticlepeer-review


Background: The addition of impedance to 24-h pH monitoring has allowed detection of weakly acidic reflux, but the extent to which pH-impedance (pH-MII) monitoring improves outcomes is unknown. Methods: This was a prospective observational study. Patients referred for pH or pH-MII monitoring completed a standardized questionnaire on improvement in the dominant symptom, their satisfaction, and treatment at 3 and 12 months after the test during a telephone interview. Results: A total of 184 patients (mean age, 52 years, range, 19–82 years; 35 % with typical symptoms; and 89 % tested off therapy) completed pH (n = 92) or pH-MII monitoring (n = 92) over a period of 15 months. The two arms were similar in terms of demographic, clinical, and endoscopic variables. Ten patients in the pH-MII arm showed evidence of weakly acidic reflux disease. There was no difference in the percentage of patients in the pH and pH-MII monitoring arms who experienced improvement in their dominant symptom after 3 (58 vs. 63 %; p = 0.621) or 12 months (66 vs. 70 %; p = 0.234), and the same was true for patient satisfaction. There were also no between-group difference in the use of proton pump inhibitors (PPIs) after 3 (63 vs. 68.5 %; p = 0.437) or 12 months (47 vs. 60.5 %; p = 0.051). PPIs were prescribed more frequently after a positive test (p 

Original languageEnglish
Pages (from-to)130-137
Number of pages8
JournalJournal of Gastroenterology
Issue number2
Publication statusPublished - Feb 1 2016


  • Gastroesophageal reflux
  • Impedance-pH monitoring
  • Patient’s outcome

ASJC Scopus subject areas

  • Gastroenterology


Dive into the research topics of 'pH Impedance vs. traditional pH monitoring in clinical practice: an outcome study'. Together they form a unique fingerprint.

Cite this