PHA-stimulated cellular immune function and T-lymphocyte subsets in major depressive disorders

A. Anesi, D. Franciotta, E. Di Paolo, E. Zardini, G. Melzi D'Eril, F. Zerbi

Research output: Contribution to journalArticlepeer-review


We measured some immunological parameters in 20 hospitalized patients with major depression and 20 age- and sex-matched healthy controls. Both enumeration of immune cells, including T-lymphocyte subpopulations, and assay of T-cell function were studied. White blood cells were evaluated with an automated cell counter, T-cell subsets with an immunobead technique, and T-cell function with a phytohemagglutinin-induced proliferation in vitro assay. We found that T-lymphocyte responses to the mitogen were significantly lower in depressed patients than in controls. All the other parameters were normal. These findings suggest that functional but not numerical changes in T-lymphocytes characterize major depressive disorders.

Original languageEnglish
Pages (from-to)17-22
Number of pages6
JournalFunctional Neurology
Issue number1
Publication statusPublished - 1994


  • lymphocyte subsets
  • major depression
  • mitogen-induced lymphocyte stimulation
  • psychoneuroimmunology

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


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