PHA-stimulated cellular immune function and T-lymphocyte subsets in major depressive disorders

A. Anesi, D. Franciotta, E. Di Paolo, E. Zardini, G. Melzi D'Eril, F. Zerbi

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

We measured some immunological parameters in 20 hospitalized patients with major depression and 20 age- and sex-matched healthy controls. Both enumeration of immune cells, including T-lymphocyte subpopulations, and assay of T-cell function were studied. White blood cells were evaluated with an automated cell counter, T-cell subsets with an immunobead technique, and T-cell function with a phytohemagglutinin-induced proliferation in vitro assay. We found that T-lymphocyte responses to the mitogen were significantly lower in depressed patients than in controls. All the other parameters were normal. These findings suggest that functional but not numerical changes in T-lymphocytes characterize major depressive disorders.

Original languageEnglish
Pages (from-to)17-22
Number of pages6
JournalFunctional Neurology
Volume9
Issue number1
Publication statusPublished - 1994

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Major Depressive Disorder
T-Lymphocyte Subsets
T-Lymphocytes
Lymphocyte Subsets
Phytohemagglutinins
Mitogens
Leukocytes
Depression

Keywords

  • lymphocyte subsets
  • major depression
  • mitogen-induced lymphocyte stimulation
  • psychoneuroimmunology

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

PHA-stimulated cellular immune function and T-lymphocyte subsets in major depressive disorders. / Anesi, A.; Franciotta, D.; Di Paolo, E.; Zardini, E.; Melzi D'Eril, G.; Zerbi, F.

In: Functional Neurology, Vol. 9, No. 1, 1994, p. 17-22.

Research output: Contribution to journalArticle

Anesi, A. ; Franciotta, D. ; Di Paolo, E. ; Zardini, E. ; Melzi D'Eril, G. ; Zerbi, F. / PHA-stimulated cellular immune function and T-lymphocyte subsets in major depressive disorders. In: Functional Neurology. 1994 ; Vol. 9, No. 1. pp. 17-22.
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