Phagocytes and their pharmacological modulation in chronic bronchitis

A. Fietta, C. Bersani, P. Mangiarotti, C. Merlini, M. Uccelli

Research output: Contribution to journalArticlepeer-review


Altered values of many functional properties of both peripheral phagocytes (neutrophils and monocytes) and alveolar macrophages were demonstrated in patients with chronic bronchitis. Out of this population 16 patients with defective phagocytosis index were included in an open randomized trial to investigate the effect of RU41740, a glycoprotein extract of Kl. pneumoniae, on this phagocytic function and its efficacy in reducing the number of exacerbations. A relationship between the restoration of the immunological parameter and the clinical improvement was demonstrated. This effect suggests that phagocytosis can play a role in protecting patients with chronic bronchitis from infectious exacerbations.

Original languageEnglish
Pages (from-to)115-122
Number of pages8
JournalInternational Journal of Immunopathology and Pharmacology
Issue number2
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Pharmacology


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