Phalangeal US velocity discriminates between normal and vertebrally fractured subjects

G. Guglielmi, M. Cammisa, A. De Serio, A. Scillitani, I. Chiodini, V. Carnevale, S. Fusilli

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Abstract

The purpose of this study was to evaluate the diagnostic sensitivity of phalangeal bone ultrasound velocity of the hand in the diagnosis of osteoporosis and to compare this technique to bone mineral density (BMD) measurement at the lumbar spine assessed by dual X-ray absorptiometry (DXA) and quantitative computed tomography (QCT). We investigated US velocity at the distal metaphysis of the proximal phalanx and spinal BMD in 101 women. Fifty-nine were healthy (mean age 50 ± 11.6 years) and 42 were osteoporotic (mean age 65 ± 6.6 years) with documented vertebral fractures. In the healthy population the relation with age was, respectively, r = -0.73 (p <0.0001) for quantitative US (QUS), r = -0.74 (p <0.0001) for QCT and r = -0.48 (p <0.01) for DXA. Both US and DXA were correlated with QCT: r = 0.74 and r = 0.77 (p <0.0001), respectively. Correlation of QUS and DXA was r = 0.56 (p <0.0001). Phalangeal US velocity and spinal BMD (QCT and DXA) values discriminate healthy from osteoporotic women. Age-adjusted logistic regression analysis of the data showed standardized odds ratios (OR) for vertebral fracture to be similar for US and DXA (OR = 1.8 and 1.5, respectively) and stronger for QCT (OR = 2.9). Phalangeal US velocity reflects age-related bone loss and differentiates between healthy and osteoporotic subjects.

Original languageEnglish
Pages (from-to)1632-1637
Number of pages6
JournalEuropean Radiology
Volume9
Issue number8
DOIs
Publication statusPublished - 1999

Fingerprint

Photon Absorptiometry
Tomography
Bone Density
Odds Ratio
Osteoporosis
Healthy Volunteers
Spine
Hand
Logistic Models
Regression Analysis
Bone and Bones
Population

Keywords

  • Bone absorptiometry
  • Bone densitometry
  • Osteoporosis
  • Quantitative ultrasound

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Phalangeal US velocity discriminates between normal and vertebrally fractured subjects. / Guglielmi, G.; Cammisa, M.; De Serio, A.; Scillitani, A.; Chiodini, I.; Carnevale, V.; Fusilli, S.

In: European Radiology, Vol. 9, No. 8, 1999, p. 1632-1637.

Research output: Contribution to journalArticle

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