TY - JOUR
T1 - Phantom limb pain
T2 - Cortical plasticity and novel therapeutic approaches
AU - Flor, Herta
AU - Birbaumer, Niels
PY - 2000
Y1 - 2000
N2 - Phantom limb pain is still a very frequent consequence of peripheral deafferentation or amputation of a limb. Recent findings from animal and neuroimaging studies suggest that phantom limb pain might be a central phenomenon, related to changes in the cortical, thalamic and spinal representation of the painful limb, and might be a type of somatosensory pain memory. Based on these assumptions, new treatment approaches focus on sensory discrimination training or motor cortex stimulation in an effort to influence cortical reorganization. Prevention of perpetuation of a somatosensory pain memory might also be possible through pharmacological agents such as N-methyl-D-aspartate antagonists and γ-aminobutyric acid agonists, substances that have been shown to influence and prevent cortical reorganization. (C) 2000 Lippincott Williams and Wilkins.
AB - Phantom limb pain is still a very frequent consequence of peripheral deafferentation or amputation of a limb. Recent findings from animal and neuroimaging studies suggest that phantom limb pain might be a central phenomenon, related to changes in the cortical, thalamic and spinal representation of the painful limb, and might be a type of somatosensory pain memory. Based on these assumptions, new treatment approaches focus on sensory discrimination training or motor cortex stimulation in an effort to influence cortical reorganization. Prevention of perpetuation of a somatosensory pain memory might also be possible through pharmacological agents such as N-methyl-D-aspartate antagonists and γ-aminobutyric acid agonists, substances that have been shown to influence and prevent cortical reorganization. (C) 2000 Lippincott Williams and Wilkins.
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U2 - 10.1097/00001503-200010000-00013
DO - 10.1097/00001503-200010000-00013
M3 - Article
C2 - 17016358
AN - SCOPUS:0033761903
VL - 13
SP - 561
EP - 564
JO - Current Opinion in Anaesthesiology
JF - Current Opinion in Anaesthesiology
SN - 0952-7907
IS - 5
ER -