Phantom movements and pain an fMRI study in upper limb amputees

Martin Lotze, Herta Flor, Wolfgang Grodd, Wolfgang Larbig, Niels Birbaumer

Research output: Contribution to journalArticle

288 Citations (Scopus)

Abstract

Using functional MRI, we investigated 14 upper limb amputees and seven healthy controls during the execution of hand and lip movements and imagined movements of the phantom limb or left hand. Only patients with phantom limb pain showed a shift of the lip representation into the deafferented primary motor and somatosensory hand areas during lip movements. Displacement of the lip representation in the primary motor and somatosensory cortex was positively correlated to the amount of phantom limb pain. Thalamic activation was only present during executed movements in the healthy controls. The cerebellum showed no evidence of reorganizational changes. In amputees, movement of the intact hand showed a level of activation similar to movement of the right dominant hand in the healthy controls. During imagination of moving the phantom hand, all patients showed significantly higher activation in the contralateral primary motor and somatosensory cortices compared with imagination of hand movements in the controls. In the patients with phantom limb pain but not the pain-free amputees, imagined movement of the phantom hand activated the neighbouring face area. These data suggest selective coactivation of the cortical hand and mouth areas in patients with phantom limb pain. This reorganizational change may be the neural correlate of phantom limb pain.

Original languageEnglish
Pages (from-to)2268-2277
Number of pages10
JournalBrain
Volume124
Issue number11
Publication statusPublished - 2001

Fingerprint

Phantom Limb
Amputees
Upper Extremity
Hand
Magnetic Resonance Imaging
Lip
Imagination
Somatosensory Cortex
Motor Cortex
Cerebellum
Mouth

Keywords

  • FMRI
  • Imagination
  • Limb amputation
  • Phantom limb pain
  • Reorganization

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Lotze, M., Flor, H., Grodd, W., Larbig, W., & Birbaumer, N. (2001). Phantom movements and pain an fMRI study in upper limb amputees. Brain, 124(11), 2268-2277.

Phantom movements and pain an fMRI study in upper limb amputees. / Lotze, Martin; Flor, Herta; Grodd, Wolfgang; Larbig, Wolfgang; Birbaumer, Niels.

In: Brain, Vol. 124, No. 11, 2001, p. 2268-2277.

Research output: Contribution to journalArticle

Lotze, M, Flor, H, Grodd, W, Larbig, W & Birbaumer, N 2001, 'Phantom movements and pain an fMRI study in upper limb amputees', Brain, vol. 124, no. 11, pp. 2268-2277.
Lotze M, Flor H, Grodd W, Larbig W, Birbaumer N. Phantom movements and pain an fMRI study in upper limb amputees. Brain. 2001;124(11):2268-2277.
Lotze, Martin ; Flor, Herta ; Grodd, Wolfgang ; Larbig, Wolfgang ; Birbaumer, Niels. / Phantom movements and pain an fMRI study in upper limb amputees. In: Brain. 2001 ; Vol. 124, No. 11. pp. 2268-2277.
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