Pharmaco-electroencephalographic characterization of fipexide hydrochloride

S. Scarone, L. Pugnetti, P. Biserni

Research output: Contribution to journalArticle

Abstract

A pilot electroencephalographic study was conducted on four healthy young male volunteers who received either 200 or 400 mg of fipexide hydrochloride orally in a double-blind placebo-controlled trial. The electroencephalograms (EEGs) from 01-Cz derivation, psychometry, blood pressure, and heart rate measurements were sampled four times at 60-minute invervals during each recording session. Absolute integrated power spectral estimates, psychometry scores, and cardiovascular measurements were statistically analyzed by means of two-way ANOVA. Results indicate that only 400-mg fipexide significantly decreases slow (1 to 4 Hz) and increases fast (10 to 30) components of the electroencephalograchic spectrum after a time delay of two hours from the time of administration. No significant psychometric or cardiovascular changes were observed. It is concluded that fipexide is effective at the central nervous system level and that its electroencephalographic profile resembles that of other dopaminergic psychotropics.

Original languageEnglish
Pages (from-to)933-939
Number of pages7
JournalCurrent Therapeutic Research
Volume39
Issue number6
Publication statusPublished - 1986

ASJC Scopus subject areas

  • Medicine(all)

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