Pharmaco-metabolomics: An emerging "omics" tool for the personalization of anticancer treatments and identification of new valuable therapeutic targets

Research output: Contribution to journalArticlepeer-review

Abstract

In the post-genomics era, metabolomics represents a new "omics" approach that in the last decade has received increased attention in the field of oncology. Metabolomics is based on the holistic study of the metabolic profile that characterizes a specific phenotype in a biological system. The metabolic profile provides a readout of the metabolic state of an individual that cannot be obtained directly from DNA genotyping, gene expression, or proteomic profiling analyses. The translational value of metabonomics in the oncology field has been demonstrated by the identification of diagnostic and prognostic biomarkers. The so-called pharmaco-metabolomic approach that is currently emerging aims to identify the individual metabolomic characteristics able to predict drug effectiveness and/or toxicity. This review presents the potential role of pharmaco-metabolomics in the future of anticancer pharmacology to achieve customized anticancer treatments and new, targeted therapeutic approaches.

Original languageEnglish
Pages (from-to)2827-2831
Number of pages5
JournalJournal of Cellular Physiology
Volume227
Issue number7
DOIs
Publication statusPublished - Jul 2012

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Cell Biology
  • Physiology

Fingerprint Dive into the research topics of 'Pharmaco-metabolomics: An emerging "omics" tool for the personalization of anticancer treatments and identification of new valuable therapeutic targets'. Together they form a unique fingerprint.

Cite this