In the last 20 years the advent of powerful antisecretory drugs has permitted a virtually complete control of gastric acid secretion. The two main categories of acid suppressant agents are represented by the antagonists of H2-receptors in the membrane of the parietal cell and the inhibitors of the proton pnmp which regulates the final cellular step in the production of acid. The pharmacodynamic properties of these compounds have been accurately described by means of continuous 24 hour gastric pH-monitoring and show some peculiar features. H2-receptor antagonists are characterized by a pulse of acid inhibition which covers a limited period (6-12 hours) of the circadian cycle and their action is maximal during the night, while is reduced during the postprandial periods. Proton pump inhibitors, on the contrary, produce a profound and prolonged acid suppression (18-20 hours) and their effect is relatively greater during the daytime than the night time.
|Translated title of the contribution||Pharmacodynamic differences between H2-receptor antagonist and proton pump inhibitors|
|Number of pages||4|
|Journal||Giornale Italiano di Endoscopia Digestiva|
|Publication status||Published - 1995|
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