Pharmacogenetics in geriatric medicine: Challenges and opportunities for clinical practice

Alberto Pilotto, Francesco Panza, Davide Seripa

Research output: Contribution to journalArticle

Abstract

The genetics of drug metabolizing enzymes, drug transporters and drug receptors is a very active area of multidisciplinary research, overlapping the interest of medicine, biology, pharmacology and genetics. Indeed, these proteins are virtually responsible for the metabolism, disposition and efficacy of most of available drugs. Variations in the gene encoding these proteins may account for the interindividual differences observed in drug efficacy, including severe clinical consequences such as therapeutic failures and adverse drug reactions. It is well known that the prevalence of both therapeutic failures and adverse drug reactions strongly increased in older subjects, and this did not seem to be always related to the presence of multiple pharmacological treatments, a common status in subjects aged 65 years and over. The present article explored some basic concepts of human genetics that may have important implications in the pharmacogenetics of drug metabolizing enzymes, drug transporters and receptors. We also focus the current knowledge on the genetic basis of the efficacy and the adverse drug reactions of the most common drugs used in the geriatric patient. Thus we explore the status of what we know and what we need to know to forward the application of pharmacogenetics in clinical practice, in order to introduce a personalized treatment project for the older people.

Original languageEnglish
Pages (from-to)621-634
Number of pages14
JournalCurrent Drug Metabolism
Volume12
Issue number7
DOIs
Publication statusPublished - Sep 2011

Fingerprint

Geriatrics
Pharmacogenetics
Medicine
Drug-Related Side Effects and Adverse Reactions
Pharmaceutical Preparations
Drug Receptors
Pharmacology
Medical Genetics
Enzymes
Therapeutics
Proteins
Gene encoding
Metabolism
Research

Keywords

  • Adverse drug reaction
  • Drug efficacy
  • Elderly
  • Genetics
  • Pharmacogenetics

ASJC Scopus subject areas

  • Pharmacology
  • Clinical Biochemistry

Cite this

Pharmacogenetics in geriatric medicine : Challenges and opportunities for clinical practice. / Pilotto, Alberto; Panza, Francesco; Seripa, Davide.

In: Current Drug Metabolism, Vol. 12, No. 7, 09.2011, p. 621-634.

Research output: Contribution to journalArticle

@article{3c2597f7799742d58c41038eb0441075,
title = "Pharmacogenetics in geriatric medicine: Challenges and opportunities for clinical practice",
abstract = "The genetics of drug metabolizing enzymes, drug transporters and drug receptors is a very active area of multidisciplinary research, overlapping the interest of medicine, biology, pharmacology and genetics. Indeed, these proteins are virtually responsible for the metabolism, disposition and efficacy of most of available drugs. Variations in the gene encoding these proteins may account for the interindividual differences observed in drug efficacy, including severe clinical consequences such as therapeutic failures and adverse drug reactions. It is well known that the prevalence of both therapeutic failures and adverse drug reactions strongly increased in older subjects, and this did not seem to be always related to the presence of multiple pharmacological treatments, a common status in subjects aged 65 years and over. The present article explored some basic concepts of human genetics that may have important implications in the pharmacogenetics of drug metabolizing enzymes, drug transporters and receptors. We also focus the current knowledge on the genetic basis of the efficacy and the adverse drug reactions of the most common drugs used in the geriatric patient. Thus we explore the status of what we know and what we need to know to forward the application of pharmacogenetics in clinical practice, in order to introduce a personalized treatment project for the older people.",
keywords = "Adverse drug reaction, Drug efficacy, Elderly, Genetics, Pharmacogenetics",
author = "Alberto Pilotto and Francesco Panza and Davide Seripa",
year = "2011",
month = "9",
doi = "10.2174/138920011796504545",
language = "English",
volume = "12",
pages = "621--634",
journal = "Current Drug Metabolism",
issn = "1389-2002",
publisher = "Bentham Science Publishers B.V.",
number = "7",

}

TY - JOUR

T1 - Pharmacogenetics in geriatric medicine

T2 - Challenges and opportunities for clinical practice

AU - Pilotto, Alberto

AU - Panza, Francesco

AU - Seripa, Davide

PY - 2011/9

Y1 - 2011/9

N2 - The genetics of drug metabolizing enzymes, drug transporters and drug receptors is a very active area of multidisciplinary research, overlapping the interest of medicine, biology, pharmacology and genetics. Indeed, these proteins are virtually responsible for the metabolism, disposition and efficacy of most of available drugs. Variations in the gene encoding these proteins may account for the interindividual differences observed in drug efficacy, including severe clinical consequences such as therapeutic failures and adverse drug reactions. It is well known that the prevalence of both therapeutic failures and adverse drug reactions strongly increased in older subjects, and this did not seem to be always related to the presence of multiple pharmacological treatments, a common status in subjects aged 65 years and over. The present article explored some basic concepts of human genetics that may have important implications in the pharmacogenetics of drug metabolizing enzymes, drug transporters and receptors. We also focus the current knowledge on the genetic basis of the efficacy and the adverse drug reactions of the most common drugs used in the geriatric patient. Thus we explore the status of what we know and what we need to know to forward the application of pharmacogenetics in clinical practice, in order to introduce a personalized treatment project for the older people.

AB - The genetics of drug metabolizing enzymes, drug transporters and drug receptors is a very active area of multidisciplinary research, overlapping the interest of medicine, biology, pharmacology and genetics. Indeed, these proteins are virtually responsible for the metabolism, disposition and efficacy of most of available drugs. Variations in the gene encoding these proteins may account for the interindividual differences observed in drug efficacy, including severe clinical consequences such as therapeutic failures and adverse drug reactions. It is well known that the prevalence of both therapeutic failures and adverse drug reactions strongly increased in older subjects, and this did not seem to be always related to the presence of multiple pharmacological treatments, a common status in subjects aged 65 years and over. The present article explored some basic concepts of human genetics that may have important implications in the pharmacogenetics of drug metabolizing enzymes, drug transporters and receptors. We also focus the current knowledge on the genetic basis of the efficacy and the adverse drug reactions of the most common drugs used in the geriatric patient. Thus we explore the status of what we know and what we need to know to forward the application of pharmacogenetics in clinical practice, in order to introduce a personalized treatment project for the older people.

KW - Adverse drug reaction

KW - Drug efficacy

KW - Elderly

KW - Genetics

KW - Pharmacogenetics

UR - http://www.scopus.com/inward/record.url?scp=79961077008&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79961077008&partnerID=8YFLogxK

U2 - 10.2174/138920011796504545

DO - 10.2174/138920011796504545

M3 - Article

C2 - 21495974

AN - SCOPUS:79961077008

VL - 12

SP - 621

EP - 634

JO - Current Drug Metabolism

JF - Current Drug Metabolism

SN - 1389-2002

IS - 7

ER -