Abstract
The genetics of drug metabolizing enzymes, drug transporters and drug receptors is a very active area of multidisciplinary research, overlapping the interest of medicine, biology, pharmacology and genetics. Indeed, these proteins are virtually responsible for the metabolism, disposition and efficacy of most of available drugs. Variations in the gene encoding these proteins may account for the interindividual differences observed in drug efficacy, including severe clinical consequences such as therapeutic failures and adverse drug reactions. It is well known that the prevalence of both therapeutic failures and adverse drug reactions strongly increased in older subjects, and this did not seem to be always related to the presence of multiple pharmacological treatments, a common status in subjects aged 65 years and over. The present article explored some basic concepts of human genetics that may have important implications in the pharmacogenetics of drug metabolizing enzymes, drug transporters and receptors. We also focus the current knowledge on the genetic basis of the efficacy and the adverse drug reactions of the most common drugs used in the geriatric patient. Thus we explore the status of what we know and what we need to know to forward the application of pharmacogenetics in clinical practice, in order to introduce a personalized treatment project for the older people.
| Original language | English |
|---|---|
| Pages (from-to) | 621-634 |
| Number of pages | 14 |
| Journal | Current Drug Metabolism |
| Volume | 12 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - Sep 2011 |
Fingerprint
Keywords
- Adverse drug reaction
- Drug efficacy
- Elderly
- Genetics
- Pharmacogenetics
ASJC Scopus subject areas
- Pharmacology
- Clinical Biochemistry
Cite this
Pharmacogenetics in geriatric medicine : Challenges and opportunities for clinical practice. / Pilotto, Alberto; Panza, Francesco; Seripa, Davide.
In: Current Drug Metabolism, Vol. 12, No. 7, 09.2011, p. 621-634.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pharmacogenetics in geriatric medicine
T2 - Challenges and opportunities for clinical practice
AU - Pilotto, Alberto
AU - Panza, Francesco
AU - Seripa, Davide
PY - 2011/9
Y1 - 2011/9
N2 - The genetics of drug metabolizing enzymes, drug transporters and drug receptors is a very active area of multidisciplinary research, overlapping the interest of medicine, biology, pharmacology and genetics. Indeed, these proteins are virtually responsible for the metabolism, disposition and efficacy of most of available drugs. Variations in the gene encoding these proteins may account for the interindividual differences observed in drug efficacy, including severe clinical consequences such as therapeutic failures and adverse drug reactions. It is well known that the prevalence of both therapeutic failures and adverse drug reactions strongly increased in older subjects, and this did not seem to be always related to the presence of multiple pharmacological treatments, a common status in subjects aged 65 years and over. The present article explored some basic concepts of human genetics that may have important implications in the pharmacogenetics of drug metabolizing enzymes, drug transporters and receptors. We also focus the current knowledge on the genetic basis of the efficacy and the adverse drug reactions of the most common drugs used in the geriatric patient. Thus we explore the status of what we know and what we need to know to forward the application of pharmacogenetics in clinical practice, in order to introduce a personalized treatment project for the older people.
AB - The genetics of drug metabolizing enzymes, drug transporters and drug receptors is a very active area of multidisciplinary research, overlapping the interest of medicine, biology, pharmacology and genetics. Indeed, these proteins are virtually responsible for the metabolism, disposition and efficacy of most of available drugs. Variations in the gene encoding these proteins may account for the interindividual differences observed in drug efficacy, including severe clinical consequences such as therapeutic failures and adverse drug reactions. It is well known that the prevalence of both therapeutic failures and adverse drug reactions strongly increased in older subjects, and this did not seem to be always related to the presence of multiple pharmacological treatments, a common status in subjects aged 65 years and over. The present article explored some basic concepts of human genetics that may have important implications in the pharmacogenetics of drug metabolizing enzymes, drug transporters and receptors. We also focus the current knowledge on the genetic basis of the efficacy and the adverse drug reactions of the most common drugs used in the geriatric patient. Thus we explore the status of what we know and what we need to know to forward the application of pharmacogenetics in clinical practice, in order to introduce a personalized treatment project for the older people.
KW - Adverse drug reaction
KW - Drug efficacy
KW - Elderly
KW - Genetics
KW - Pharmacogenetics
UR - http://www.scopus.com/inward/record.url?scp=79961077008&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79961077008&partnerID=8YFLogxK
U2 - 10.2174/138920011796504545
DO - 10.2174/138920011796504545
M3 - Article
C2 - 21495974
AN - SCOPUS:79961077008
VL - 12
SP - 621
EP - 634
JO - Current Drug Metabolism
JF - Current Drug Metabolism
SN - 1389-2002
IS - 7
ER -