Abstract
Personalized medicine - the adaptation of therapies based on an individual's genetic and molecular profile - is one of the most promising aspects of modern medicine. The identification of the relation between genotype and drug response, including both the therapeutic effect and side effect profile, is expected to deeply affect medical practice. In this paper, we review the current knowledge about the genes related to antidepressant treatment response and provide methodologic proposals for future studies. We have mainly focused on genes associated with pharmacodynamics, for which a list of promising genes has been identified despite some inconsistency across studies. We have also synthesized the main results for pharmacokinetic genes, although so far they seem less relevant than those for pharmaco dynamic genes. We discuss possible reasons for these inconsistent findings and propose new study designs.
| Original language | English |
|---|---|
| Pages (from-to) | 87-113 |
| Number of pages | 27 |
| Journal | Journal of Psychiatry and Neuroscience |
| Volume | 36 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2011 |
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ASJC Scopus subject areas
- Psychiatry and Mental health
- Biological Psychiatry
- Pharmacology (medical)
Cite this
Pharmacogenetics of antidepressant response. / Porcelli, Stefano; Drago, Antonio; Fabbri, Chiara; Gibiino, Sara; Calati, Raffaella; Serretti, Alessandro.
In: Journal of Psychiatry and Neuroscience, Vol. 36, No. 2, 2011, p. 87-113.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pharmacogenetics of antidepressant response
AU - Porcelli, Stefano
AU - Drago, Antonio
AU - Fabbri, Chiara
AU - Gibiino, Sara
AU - Calati, Raffaella
AU - Serretti, Alessandro
PY - 2011
Y1 - 2011
N2 - Personalized medicine - the adaptation of therapies based on an individual's genetic and molecular profile - is one of the most promising aspects of modern medicine. The identification of the relation between genotype and drug response, including both the therapeutic effect and side effect profile, is expected to deeply affect medical practice. In this paper, we review the current knowledge about the genes related to antidepressant treatment response and provide methodologic proposals for future studies. We have mainly focused on genes associated with pharmacodynamics, for which a list of promising genes has been identified despite some inconsistency across studies. We have also synthesized the main results for pharmacokinetic genes, although so far they seem less relevant than those for pharmaco dynamic genes. We discuss possible reasons for these inconsistent findings and propose new study designs.
AB - Personalized medicine - the adaptation of therapies based on an individual's genetic and molecular profile - is one of the most promising aspects of modern medicine. The identification of the relation between genotype and drug response, including both the therapeutic effect and side effect profile, is expected to deeply affect medical practice. In this paper, we review the current knowledge about the genes related to antidepressant treatment response and provide methodologic proposals for future studies. We have mainly focused on genes associated with pharmacodynamics, for which a list of promising genes has been identified despite some inconsistency across studies. We have also synthesized the main results for pharmacokinetic genes, although so far they seem less relevant than those for pharmaco dynamic genes. We discuss possible reasons for these inconsistent findings and propose new study designs.
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UR - http://www.scopus.com/inward/citedby.url?scp=79953076020&partnerID=8YFLogxK
U2 - 10.1503/jpn.100059
DO - 10.1503/jpn.100059
M3 - Article
VL - 36
SP - 87
EP - 113
JO - Journal of Psychiatry and Neuroscience
JF - Journal of Psychiatry and Neuroscience
SN - 1180-4882
IS - 2
ER -