Nowadays, the efficacy of antidepressant treatment and the profile of side effects are not predictable: sociodemographic and clinical variables have not provided clinicians with consistent support. Emerging evidence reports promising results from the genetic approach: pharmacogenetics identifies which genetic variations are associated with drug treatment outcome. Both pharmacodynamic and pharmacokinetic key genes have been investigated, and even though consistent conclusions are yet to come, several lines of evidence have led researchers to assume a promising future of effective pharmacogenetic-based pretreatment assessment. The most important antidepressant pharmacogenetic results in this field are reviewed in this chapter and future research lines are proposed.
ASJC Scopus subject areas