Pharmacogenetics of human androgens and prostatic diseases

G. Novelli, K. Margiotti, F. Sangiuolo, J. K V Reichardt

Research output: Contribution to journalArticle

Abstract

Prostate cancer (PCa) and benign prostatic hypertrophy (BPH) are two common and growing public health problems in the Western world. We review here the recent biochemical and pharmacogenetic literature related to these two prostatic disorders. We focus first on constitutional ('germline') single nucleotide polymorphism (SNPs) at the steroid 5α-reductase (SRD5A2) locus, which encodes the human prostatic (or Type II) steroid 5α-reductase enzyme. The investigations reviewed point to several uses of personalised medicine at the SRD5A2 locus. In addition, we report on recent identification of somatic pharmacogenetic alterations at the androgen receptor (AR) locus, which encodes the human androgen receptor, suggesting that this also may be a fruitful field of investigation, with important clinical applications. Pharmacogenomic investigation of constitutional and somatic DNA changes in human genes predisposing to cancer may lead to significant advances in chemoprevention, presymptomatic diagnosis and improved treatment of PCa.

Original languageEnglish
Pages (from-to)65-72
Number of pages8
JournalPharmacogenomics
Volume2
Issue number1
DOIs
Publication statusPublished - 2001

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Keywords

  • Androgen receptor
  • Benign prostatic hypertrophy
  • Chemoprevention
  • Finasteride
  • Personalised medicine
  • Pharmacogenetics
  • Prostate cancer
  • Single nucleotide polymorphism (SNP)
  • Steroid 5α-reductase (SRD5A2)
  • Treatment

ASJC Scopus subject areas

  • Pharmacology
  • Genetics(clinical)

Cite this

Novelli, G., Margiotti, K., Sangiuolo, F., & Reichardt, J. K. V. (2001). Pharmacogenetics of human androgens and prostatic diseases. Pharmacogenomics, 2(1), 65-72. https://doi.org/10.1517/14622416.2.1.65