TY - JOUR
T1 - Pharmacogenetics of lithium prophylaxis in mood disorders
T2 - Analysis of COMT, MAO-A, and Gβ3 variants
AU - Serretti, Alessandro
AU - Lorenzi, Cristina
AU - Lilli, Roberta
AU - Mandelli, Laura
AU - Pirovano, Adele
AU - Smeraldi, Enrico
PY - 2002/5/8
Y1 - 2002/5/8
N2 - We studied the possible association between the prophylactic efficacy of lithium in mood disorders and the following gene variants: catechol-O-methyltransferase (COMT) G158A, monoamine oxydase A (MAO-A) 30-bp repeat, G-protein β 3-subunit (Gβ3) C825T. A total of 201 subjects affected by bipolar (n = 160) and major depressive (n = 41) disorder were followed prospectively for an average of 59.8 months and were typed for their gene variants using PCR techniques. COMT, MAO-A, and Gβ3 variants were not associated with lithium outcome, even when possible stratification effects such as sex, polarity, age at onset, duration of lithium treatment, and previous episodes were included in the model. The pathways influenced by those variants are not therefore involved with long-term lithium outcome in our sample.
AB - We studied the possible association between the prophylactic efficacy of lithium in mood disorders and the following gene variants: catechol-O-methyltransferase (COMT) G158A, monoamine oxydase A (MAO-A) 30-bp repeat, G-protein β 3-subunit (Gβ3) C825T. A total of 201 subjects affected by bipolar (n = 160) and major depressive (n = 41) disorder were followed prospectively for an average of 59.8 months and were typed for their gene variants using PCR techniques. COMT, MAO-A, and Gβ3 variants were not associated with lithium outcome, even when possible stratification effects such as sex, polarity, age at onset, duration of lithium treatment, and previous episodes were included in the model. The pathways influenced by those variants are not therefore involved with long-term lithium outcome in our sample.
KW - Bipolar disorder
KW - Follow-up studies
KW - Lithium
KW - Pharmacogenetics
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U2 - 10.1002/ajmg.10357
DO - 10.1002/ajmg.10357
M3 - Article
C2 - 11992559
AN - SCOPUS:0037042015
VL - 114
SP - 370
EP - 379
JO - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
JF - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
SN - 1552-4841
IS - 4
ER -