Pharmacogenetics of methylphenidate response in attention deficit/hyperactivity disorder: Association with the dopamine transporter gene (SLC6A3)

D. Purper-Ouakil, M. Wohl, S. Orejarena, S. Cortese, C. Boni, M. Asch, M. C. Mouren, P. Gorwood

Research output: Contribution to journalArticle

Abstract

Pharmacogenetic studies investigating the 40-bp VNTR polymorphism at SLC6A3 and methylphenidate response have shown conflicting results and large differences in study design and efficacy endpoints. Our objective was to investigate the relation between the 30-VNTR at SLC6A3 and variability in methylphenidate response in a sample of 141 ADHD children and adolescents, assessed before and after methylphenidate treatment with both clinical and neuropsychological outcome measures. 10-R homozygotes were significantly overrepresented in the low response group, but no genotype effect was shown in cognitive variables improvement. A meta-analysis of pharmacogenetic studies with comparable data (responders vs. non-responders) on a total of 475 subjects showed a significant association between the 10-10 genotype and low rates of methylphenidate response (mean Odds Ratio = 0.46; 95% CI [0.28-0.76]). Heterogeneity between these studies did not reach a significant level but, as publications with different endpoints were excluded from this meta-analysis, our results do not rule out a possible influence of study design.

Original languageEnglish
Pages (from-to)1425-1430
Number of pages6
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Volume147
Issue number8
DOIs
Publication statusPublished - Dec 5 2008

Keywords

  • Attention deficit/hyperactivity disorder
  • Meta-analysis
  • Methylphenidate
  • Pharmacogenetics

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

Fingerprint Dive into the research topics of 'Pharmacogenetics of methylphenidate response in attention deficit/hyperactivity disorder: Association with the dopamine transporter gene (SLC6A3)'. Together they form a unique fingerprint.

  • Cite this