Pharmacogenetics of selective serotonin reuptake inhibitor response

A 6-month follow-up

Alessandro Serretti, Raffaella Zanardi, Linda Franchini, Paola Artioli, Danilo Dotoli, Adele Pirovano, Enrico Smeraldi

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Background: We previously reported the association between some genetic factors and short-term antidepressant outcome. In the present paper we investigated the same gene variants in a prospective 6-months naturalistic follow-up. Methods: The sample included 185 inpatients affected by recurrent major depression consecutively admitted to the Psychiatric Inpatient Unit of San Raffaele Hospital from 1998 to 2003 and prospectively followed for 6 months after their recovery. All the patients were undertaking continuation therapy. The functional polymorphism in the upstream regulatory region of the serotonin transporter gene (SERTPR), the tryptophan hydroxylase A218C substitution, a VNTR polymorphism located 1.2 kb upstream of the monoamine oxidase-A coding sequences, the CLOCK gene T3111C and the PER3exon15 gene T1940G substitutions were analysed, using PCR-based techniques. Results: No association was found between clinical variables and relapses; subjects showing TT genotype at CLOCK gene tended to relapse within 6 months after recovery more than TC and CC subjects taken together. A non-significant tendency of SERTPR* s/s subjects to a minor frequency of relapse was also observed. Conclusion: Some subjects showing remission after acute treatment relapsed within 6 months, despite undertaking a maintenance treatment; the causes could be heterogeneous, but CLOCK gene variants may influence the outcome.

Original languageEnglish
Pages (from-to)607-613
Number of pages7
JournalPharmacogenetics
Volume14
Issue number9
DOIs
Publication statusPublished - Sep 2004

Fingerprint

Pharmacogenetics
Serotonin Uptake Inhibitors
Genes
Serotonin Plasma Membrane Transport Proteins
Recurrence
Inpatients
Tryptophan Hydroxylase
Nucleic Acid Regulatory Sequences
Monoamine Oxidase
Antidepressive Agents
Psychiatry
Therapeutics
Genotype
Polymerase Chain Reaction

Keywords

  • Follow-up
  • Polymorphism
  • Recurrent major depression
  • SSRI

ASJC Scopus subject areas

  • Genetics
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Serretti, A., Zanardi, R., Franchini, L., Artioli, P., Dotoli, D., Pirovano, A., & Smeraldi, E. (2004). Pharmacogenetics of selective serotonin reuptake inhibitor response: A 6-month follow-up. Pharmacogenetics, 14(9), 607-613. https://doi.org/10.1097/00008571-200409000-00005

Pharmacogenetics of selective serotonin reuptake inhibitor response : A 6-month follow-up. / Serretti, Alessandro; Zanardi, Raffaella; Franchini, Linda; Artioli, Paola; Dotoli, Danilo; Pirovano, Adele; Smeraldi, Enrico.

In: Pharmacogenetics, Vol. 14, No. 9, 09.2004, p. 607-613.

Research output: Contribution to journalArticle

Serretti, A, Zanardi, R, Franchini, L, Artioli, P, Dotoli, D, Pirovano, A & Smeraldi, E 2004, 'Pharmacogenetics of selective serotonin reuptake inhibitor response: A 6-month follow-up', Pharmacogenetics, vol. 14, no. 9, pp. 607-613. https://doi.org/10.1097/00008571-200409000-00005
Serretti A, Zanardi R, Franchini L, Artioli P, Dotoli D, Pirovano A et al. Pharmacogenetics of selective serotonin reuptake inhibitor response: A 6-month follow-up. Pharmacogenetics. 2004 Sep;14(9):607-613. https://doi.org/10.1097/00008571-200409000-00005
Serretti, Alessandro ; Zanardi, Raffaella ; Franchini, Linda ; Artioli, Paola ; Dotoli, Danilo ; Pirovano, Adele ; Smeraldi, Enrico. / Pharmacogenetics of selective serotonin reuptake inhibitor response : A 6-month follow-up. In: Pharmacogenetics. 2004 ; Vol. 14, No. 9. pp. 607-613.
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