Abstract
Background: We previously reported the association between some genetic factors and short-term antidepressant outcome. In the present paper we investigated the same gene variants in a prospective 6-months naturalistic follow-up. Methods: The sample included 185 inpatients affected by recurrent major depression consecutively admitted to the Psychiatric Inpatient Unit of San Raffaele Hospital from 1998 to 2003 and prospectively followed for 6 months after their recovery. All the patients were undertaking continuation therapy. The functional polymorphism in the upstream regulatory region of the serotonin transporter gene (SERTPR), the tryptophan hydroxylase A218C substitution, a VNTR polymorphism located 1.2 kb upstream of the monoamine oxidase-A coding sequences, the CLOCK gene T3111C and the PER3exon15 gene T1940G substitutions were analysed, using PCR-based techniques. Results: No association was found between clinical variables and relapses; subjects showing TT genotype at CLOCK gene tended to relapse within 6 months after recovery more than TC and CC subjects taken together. A non-significant tendency of SERTPR* s/s subjects to a minor frequency of relapse was also observed. Conclusion: Some subjects showing remission after acute treatment relapsed within 6 months, despite undertaking a maintenance treatment; the causes could be heterogeneous, but CLOCK gene variants may influence the outcome.
| Original language | English |
|---|---|
| Pages (from-to) | 607-613 |
| Number of pages | 7 |
| Journal | Pharmacogenetics |
| Volume | 14 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - Sep 2004 |
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Keywords
- Follow-up
- Polymorphism
- Recurrent major depression
- SSRI
ASJC Scopus subject areas
- Genetics
- Pharmacology, Toxicology and Pharmaceutics(all)
Cite this
Pharmacogenetics of selective serotonin reuptake inhibitor response : A 6-month follow-up. / Serretti, Alessandro; Zanardi, Raffaella; Franchini, Linda; Artioli, Paola; Dotoli, Danilo; Pirovano, Adele; Smeraldi, Enrico.
In: Pharmacogenetics, Vol. 14, No. 9, 09.2004, p. 607-613.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pharmacogenetics of selective serotonin reuptake inhibitor response
T2 - A 6-month follow-up
AU - Serretti, Alessandro
AU - Zanardi, Raffaella
AU - Franchini, Linda
AU - Artioli, Paola
AU - Dotoli, Danilo
AU - Pirovano, Adele
AU - Smeraldi, Enrico
PY - 2004/9
Y1 - 2004/9
N2 - Background: We previously reported the association between some genetic factors and short-term antidepressant outcome. In the present paper we investigated the same gene variants in a prospective 6-months naturalistic follow-up. Methods: The sample included 185 inpatients affected by recurrent major depression consecutively admitted to the Psychiatric Inpatient Unit of San Raffaele Hospital from 1998 to 2003 and prospectively followed for 6 months after their recovery. All the patients were undertaking continuation therapy. The functional polymorphism in the upstream regulatory region of the serotonin transporter gene (SERTPR), the tryptophan hydroxylase A218C substitution, a VNTR polymorphism located 1.2 kb upstream of the monoamine oxidase-A coding sequences, the CLOCK gene T3111C and the PER3exon15 gene T1940G substitutions were analysed, using PCR-based techniques. Results: No association was found between clinical variables and relapses; subjects showing TT genotype at CLOCK gene tended to relapse within 6 months after recovery more than TC and CC subjects taken together. A non-significant tendency of SERTPR* s/s subjects to a minor frequency of relapse was also observed. Conclusion: Some subjects showing remission after acute treatment relapsed within 6 months, despite undertaking a maintenance treatment; the causes could be heterogeneous, but CLOCK gene variants may influence the outcome.
AB - Background: We previously reported the association between some genetic factors and short-term antidepressant outcome. In the present paper we investigated the same gene variants in a prospective 6-months naturalistic follow-up. Methods: The sample included 185 inpatients affected by recurrent major depression consecutively admitted to the Psychiatric Inpatient Unit of San Raffaele Hospital from 1998 to 2003 and prospectively followed for 6 months after their recovery. All the patients were undertaking continuation therapy. The functional polymorphism in the upstream regulatory region of the serotonin transporter gene (SERTPR), the tryptophan hydroxylase A218C substitution, a VNTR polymorphism located 1.2 kb upstream of the monoamine oxidase-A coding sequences, the CLOCK gene T3111C and the PER3exon15 gene T1940G substitutions were analysed, using PCR-based techniques. Results: No association was found between clinical variables and relapses; subjects showing TT genotype at CLOCK gene tended to relapse within 6 months after recovery more than TC and CC subjects taken together. A non-significant tendency of SERTPR* s/s subjects to a minor frequency of relapse was also observed. Conclusion: Some subjects showing remission after acute treatment relapsed within 6 months, despite undertaking a maintenance treatment; the causes could be heterogeneous, but CLOCK gene variants may influence the outcome.
KW - Follow-up
KW - Polymorphism
KW - Recurrent major depression
KW - SSRI
UR - http://www.scopus.com/inward/record.url?scp=4644332454&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=4644332454&partnerID=8YFLogxK
U2 - 10.1097/00008571-200409000-00005
DO - 10.1097/00008571-200409000-00005
M3 - Article
VL - 14
SP - 607
EP - 613
JO - Pharmacogenetics
JF - Pharmacogenetics
SN - 0960-314X
IS - 9
ER -