TY - JOUR
T1 - Pharmacogenomic approaches for tailored anti-leukemic therapy in children
AU - Stocco, G.
AU - Franca, R.
AU - Verzegnassi, F.
AU - Londero, M.
AU - Rabusin, M.
AU - Decorti, G.
PY - 2013/6
Y1 - 2013/6
N2 - Several lympholytic and cytotoxic agents are used in acute lymphoblastic leukemia (ALL) polychemotherapy. Genetic variants for cellular components involved in the pharmacokinetics and pharmacodynamics of these drugs can influence the pharmacological response, and molecular characterization of these genetic variants could be helpful for the comprehension of the mechanisms of resistance or increased sensitivity. The purpose of this review is to carry out an update of recent publications on genes that might influence ALL treatment in terms of outcome and/or toxicity and to underlie the role of genetic variants, particularly single nucleotide polymorphisms (SNP), in predicting clinical response, with particular reference to the current protocol for ALL therapy used in Italy, AIEOP-BFM ALL 2009.
AB - Several lympholytic and cytotoxic agents are used in acute lymphoblastic leukemia (ALL) polychemotherapy. Genetic variants for cellular components involved in the pharmacokinetics and pharmacodynamics of these drugs can influence the pharmacological response, and molecular characterization of these genetic variants could be helpful for the comprehension of the mechanisms of resistance or increased sensitivity. The purpose of this review is to carry out an update of recent publications on genes that might influence ALL treatment in terms of outcome and/or toxicity and to underlie the role of genetic variants, particularly single nucleotide polymorphisms (SNP), in predicting clinical response, with particular reference to the current protocol for ALL therapy used in Italy, AIEOP-BFM ALL 2009.
KW - Acute lymphoblastic leukemia
KW - Chemotherapy
KW - Pharmacogenetics
UR - http://www.scopus.com/inward/record.url?scp=84877931372&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84877931372&partnerID=8YFLogxK
U2 - 10.2174/0929867311320170008
DO - 10.2174/0929867311320170008
M3 - Article
C2 - 23458619
AN - SCOPUS:84877931372
VL - 20
SP - 2237
EP - 2253
JO - Current Medicinal Chemistry
JF - Current Medicinal Chemistry
SN - 0929-8673
IS - 17
ER -