TY - JOUR
T1 - Farmacogenomica e chemioterapia
T2 - Attuali conoscenze
AU - Paris, Ida
AU - Cappellini, Gian Carlo Antonini
AU - Malaguti, Paola
AU - Bassanelli, Maria
AU - Marchetti, Paolo
PY - 2010/7
Y1 - 2010/7
N2 - Genetic factors could alter drug metabolism and activity and could predict drug toxicity and/or efficacy. Several chemotherapy agents are administered in different schedules for the treatment of different cancer histotypes. The most used drug in the treatment of gastro-intestinal, head and neck and breast neoplasms is the 5-fluorouracil (5-FU). Capecitabine is a prodrug of 5-FU. Cisplatin based chemotherapy is administered in the treatment of lung, genitourinary tract, head and neck, occult neoplasms, mesothelioma and melanoma. Taxanes are used in lung, breast, head and neck, genitourinary tract neoplasms and sarcomas. Determination of polymorphisms in metabolizing enzymes before the administration of chemotherapy could offer new strategies for optimizing the treatment of individual patients.
AB - Genetic factors could alter drug metabolism and activity and could predict drug toxicity and/or efficacy. Several chemotherapy agents are administered in different schedules for the treatment of different cancer histotypes. The most used drug in the treatment of gastro-intestinal, head and neck and breast neoplasms is the 5-fluorouracil (5-FU). Capecitabine is a prodrug of 5-FU. Cisplatin based chemotherapy is administered in the treatment of lung, genitourinary tract, head and neck, occult neoplasms, mesothelioma and melanoma. Taxanes are used in lung, breast, head and neck, genitourinary tract neoplasms and sarcomas. Determination of polymorphisms in metabolizing enzymes before the administration of chemotherapy could offer new strategies for optimizing the treatment of individual patients.
KW - 5-fluorouracil toxicity
KW - Dihydropyrimidine dehydrogenase
KW - ERCC1 expression in non small cell lung cancer
KW - Irinotecan toxicity
KW - MTHFR
KW - Taxanes and drug transporters
KW - Thymidylate synthase gene polymorphisms
KW - UGT1A1
UR - http://www.scopus.com/inward/record.url?scp=77957332196&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77957332196&partnerID=8YFLogxK
U2 - 10.1701/508.6078
DO - 10.1701/508.6078
M3 - Articolo
C2 - 20842953
AN - SCOPUS:77957332196
VL - 101
SP - 277
EP - 282
JO - Recenti Progressi in Medicina
JF - Recenti Progressi in Medicina
SN - 0034-1193
IS - 7-8
ER -