Pharmacogenomics and personalized medicine

E. Cecchin, G. Stocco

Research output: Contribution to journalArticlepeer-review

Abstract

Pharmacogenomics is one of the emerging approaches to precision medicine, tailoring drug selection and dosing to the patient’s genetic features. In recent years, several pharmacogenetic guidelines have been published by international scientific consortia, but the uptake in clinical practice is still poor. Many coordinated international efforts are ongoing in order to overcome the existing barriers to pharmacogenomic implementation. On the other hand, existing validated pharmacogenomic markers can explain only a minor part of the observed clinical variability in the therapeutic outcome. New investigational approaches are warranted, including the study of the pharmacogenomic role of the immune system genetics and of previously neglected rare genetic variants, reported to account for a large part of the inter-individual variability in drug metabolism. In this Special Issue, we collected a series of articles covering many aspects of pharmacogenomics. These include clinical implementation of pharmacogenomics in clinical practice, development of tools or infrastractures to support this process, research of new pharmacogenomics markers to increase drug efficacy and safety, and the impact of rare genetic variants in pharmacogenomics. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalGenes
Volume11
Issue number6
DOIs
Publication statusPublished - 2020

Keywords

  • Human genetics
  • Personalized medicine
  • Pharmacogenomics
  • Pharmacology
  • acenocoumarol
  • anthracycline
  • antineoplastic alkaloid
  • asparaginase
  • azathioprine
  • cisplatin
  • clopidogrel
  • cytarabine
  • glucocorticoid
  • irinotecan
  • mercaptopurine
  • methotrexate
  • platinum derivative
  • sorafenib
  • vincristine
  • warfarin
  • acute lymphoblastic leukemia
  • adjuvant therapy
  • Article
  • basal like breast cancer
  • clinical practice
  • drug efficacy
  • drug interaction
  • drug metabolism
  • drug safety
  • electronic health record
  • epigenetics
  • genetic polymorphism
  • genetic variability
  • genotype
  • high throughput sequencing
  • human
  • human epidermal growth factor receptor 2 positive breast cancer
  • inflammatory bowel disease
  • microarray analysis
  • nephrotoxicity
  • neuropathy
  • ovary cancer
  • personalized medicine
  • pharmacogenomics
  • prescription

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