Pharmacogenomics in dermatology: From susceptibility genes to personalized therapy

Carlo Pincelli, Marco Pignatti, Riccardo G. Borroni

Research output: Contribution to journalArticlepeer-review

Abstract

A significant proportion of patients with skin disease do not respond to treatment and adverse drug reactions are a common problem. Genetic factors are important determinants for both drug efficacy and toxicity. The fields of pharmacogenetics and pharmacogenomics examine inter- individual variations in the DNA sequence that are related to drug efficacy and toxicity. Here, we present pharmacogenomic data relevant to dermatology and explore the role of dermatologists in identifying patients who may respond to treatment or experience adverse drug reactions.

Original languageEnglish
Pages (from-to)337-349
Number of pages13
JournalExperimental Dermatology
Volume18
Issue number4
DOIs
Publication statusPublished - 2009

Keywords

  • Adverse drug reactions
  • Atopic dermatitis
  • Melanoma
  • Pharmacogenetics
  • Pharmacogenomics
  • Psoriasis

ASJC Scopus subject areas

  • Dermatology
  • Molecular Biology
  • Biochemistry

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