Pharmacogenomics of multifactorial diseases: A focus on psoriatic arthritis

Raffaella Cascella, Claudia Strafella, G. Longo, Mara Maccarone, P. Borgiani, Federica Sangiuolo, Giuseppe Novelli, Emiliano Giardina

Research output: Contribution to journalReview articlepeer-review

Abstract

This review will outline the current pharmacogenomics knowledge about psoriatic arthritis with a special attention to the perspectives and the challenges for its implementation in the clinical practice. To date, different drugs have been developed to contrast the symptoms and the progression of psoriatic arthritis. However, patients have shown high variability of drug response in relation to their genetic makeup. In this context, the advances made in the knowledge and the potentialities of genome-drugs associations paved the path for the development of a precision medicine. In fact, these associations may be successfully combined with the environment information to provide new strategies able to prevent and improve the disease management as well as to enhance the patients quality of life.

Original languageEnglish
Pages (from-to)943-951
Number of pages9
JournalPharmacogenomics
Volume17
Issue number8
DOIs
Publication statusPublished - Jun 1 2016

Keywords

  • healthcare approach
  • pharmacogenomics
  • precision/personalized medicine
  • psoriatic arthritis

ASJC Scopus subject areas

  • Pharmacology
  • Genetics
  • Molecular Medicine

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