Pharmacokinetic and pharmacodynamic determinants of early virological response to enfuvirtide-based regimens in HIV-positive patients

Daniel Gonzalez de Requena, Stefano Bonora, Antonella Castagna, Hamid Hasson, Diego Aguilar Marucco, Antonio D'avolio, Mauro Sciandra, Laura Trentini, Andrea Calcagno, Adriano Lazzarin, Giovanni Di Perri

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Early virological response (VR) to enfuvirtide-based salvage regimens at week 12 has been described as a predictor of long-term therapeutic success. The relationship between enfuvirtide plasma exposure and VR has not yet been investigated in the clinical setting. Our aim was to investigate the role of enfuvirtide plasma exposure as a determinant of early VR in the clinical setting. Methods: Forty-two multidrug-experienced patients starting a salvage enfuvirtide-based regimen were prospectively evaluated over a 12 week period. HIV-RNA levels and enfuvirtide Ctrough were regularly measured. VR was considered as achievement of viral load (VL) undetectability and/or a decrease of more than 1 log at week 12. Results: Optimized background score (OBS) and enfuvirtide Ctrough concentrations were associated with VL decrease at week 12. An OBS ≥2 and enfuvirtide Ctrough >2100 ng/mL were associated with VR. The pharmacokinetic/pharmacodynamic (PK/PD) analysis confirmed this exposure-response relationship both in the total population and in different groups according to OBS 50 were calculated for the OBS 0 (0.31 versus 0.21 log) and Imax (-64 versus -3.33 log). Conclusions: Enfuvirtide plasma exposure and OBS were found to significantly influence the magnitude and rate of early VR. The PK/PD modelling of enfuvirtide concentrations was different in our clinical setting, compared with previous data obtained under trial conditions. Therefore, optimization of enfuvirtide plasma exposure could deserve further evaluation as a determinant of therapeutic response in HIV-positive patients.

Original languageEnglish
Pages (from-to)384-387
Number of pages4
JournalJournal of Antimicrobial Chemotherapy
Volume62
Issue number2
DOIs
Publication statusPublished - Aug 2008

Keywords

  • Efficacy
  • Entry inhibitor
  • PK/PD

ASJC Scopus subject areas

  • Pharmacology
  • Microbiology

Fingerprint

Dive into the research topics of 'Pharmacokinetic and pharmacodynamic determinants of early virological response to enfuvirtide-based regimens in HIV-positive patients'. Together they form a unique fingerprint.

Cite this