Pharmacokinetic approach to in vitro testing of ovarian cancer cell sensitivity

L. Morasca, G. Balconi, E. Erba, M. D’Incaici, L. Ottolenghi, A. Salmona, S. Garattini

Research output: Contribution to journalArticlepeer-review

Abstract

Cell populations obtained from ovarian cancer specimens were seeded in primary culture and morphologically identified as cancer cells. Methotrexate, cytosine arabinoside, 5-fluorouracil, actinomycin D, melphalan, and adriamycin were added to the culture medium at different concentrations and for various periods of time. The results are discussed in relation to the pharmacokinetic availability of drugs in the plasma compartment of patients treated by different therapeutic regimens. Totally inactive drugs can be identified by comparing plasma levels with active concentrations while for drugs active in vitro at concentrations in the range of pharmacokinetic levels, the percentage of responders among patients might be explained by the intrinsic variability of cancer cells.

Original languageEnglish
Pages (from-to)169-173
Number of pages5
JournalOncology
Volume37
Issue number3
DOIs
Publication statusPublished - 1980

Keywords

  • Antineoplastic agents
  • Ovarian cancer
  • Pharmacokinetics
  • Tissue culture

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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