Pharmacokinetic of cyclosporine microemulsion in pediatric kidney recipients receiving a quadruple immunosuppressive regimen: The value of C2 blood levels

Mariana Ferraresso, Luciana Ghio, Graziella Zacchello, Luisa Murer, Fabrizio Ginevri, Francesco Perfumo, Gian Franco Zanon, Ines Fontana, Alessandro Amore, Alberto Edefonti, Sara Vigano, Massimo Cardillo, Mario Scalamogna

Research output: Contribution to journalArticlepeer-review

Abstract

Background. The management of cyclosporine therapy in pediatric kidney-transplant recipients is largely based on single center's experience rather than on a univocal pharmacokinetic approach based on therapeutic drug monitoring. A prospective multicenter trial was designed to address the question whether C2 blood level monitoring of cyclosporine microemulsion therapy is feasible in the pediatric setting. Methods. Sixty-four pediatric kidney-transplant recipients receiving a triple immunosuppressive regimen based on cyclosporine microemulsion had their cyclosporine dose adjusted to the same protocol-defined C2 targets from the time of the transplant until 2 years posttransplant. The interim analyses after 1 year of enrolment is presented in this study. Results. One-year patient and graft survival were 100% and 94.8%, respectively. One-year rejection rate was 15%. C2 management of cyclosporine did not affect graft function: 1-year serum creatinine and glomerular filtration rate were 1.3±1 mg/mL and 71.2±20 mL/min/1.73 m2, respectively. C2 was the best single-point predictor of the area under the concentration curve throughout the entire follow-up, with a mean coefficient of correlation of 0.97±0.01. Conclusions. C2 management of cyclosporine microemulsion therapy is effective and safe in pediatric kidney-transplant recipients given a combined immunosuppressive treatment.

Original languageEnglish
Pages (from-to)1164-1168
Number of pages5
JournalTransplantation
Volume79
Issue number9
DOIs
Publication statusPublished - May 15 2005

Keywords

  • Cyclosporine
  • Pediatric immunosuppression
  • Pediatric kidney transplantation
  • Pharmacokinetic
  • Prospective study

ASJC Scopus subject areas

  • Transplantation
  • Immunology

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