Five prodrugs of S(+)-2-(6-methoxy-2-naphthyl)propionic acid (naproxen), in which the drug was bound by ester linkages to diethyleneglycol (I), triethyleneglycol (II), octanediol (III), butyl- triethyleneglycol (IV), and butyl-tetraethyleneglycol (V), respectively, were prepared and tested for their pharmacokinetic properties after oral administration. It was found that bioavailabilities decreased in the order, and in all cases were lower than that of the free drug.
- Naproxen pharmacokinetics
- Oligomeric poly(ethyleneglycol)s
- Oligomeric prodrugs
- S(+)-2-(6-methoxy-2-naphthyl)propionic acid
ASJC Scopus subject areas
- Biomedical Engineering