Pharmacokinetic results on naproxen prodrugs based on poly(Ethyleneglycol)s

E. Ranucci, L. Sartore, I. Peroni, R. Latini, R. Bernasconi, P. Ferruti

Research output: Contribution to journalArticle

Abstract

Five prodrugs of S(+)-2-(6-methoxy-2-naphthyl)propionic acid (naproxen), in which the drug was bound by ester linkages to diethyleneglycol (I), triethyleneglycol (II), octanediol (III), butyl- triethyleneglycol (IV), and butyl-tetraethyleneglycol (V), respectively, were prepared and tested for their pharmacokinetic properties after oral administration. It was found that bioavailabilities decreased in the order, and in all cases were lower than that of the free drug.

Original languageEnglish
Pages (from-to)141-147
Number of pages7
JournalJournal of Biomaterials Science, Polymer Edition
Volume6
Issue number2
DOIs
Publication statusPublished - Jan 1 1995

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Keywords

  • Naproxen pharmacokinetics
  • Oligomeric poly(ethyleneglycol)s
  • Oligomeric prodrugs
  • S(+)-2-(6-methoxy-2-naphthyl)propionic acid

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomedical Engineering
  • Biomaterials

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