Pharmacokinetic studies of Prethcamide in rats

T. Szumilo, M. L. Canobbio, R. Fanelli, E. Mussini, F. Marcucci

Research output: Contribution to journalArticle

Abstract

A simple and sensitive gas chromatographic method for determination of Prethcamide components (I and II) in whole blood and tissues of rats has been developed. The method was used to study disposition of Prethcamide after oral and intravenous administration (60 mg/kg) to rats. Half-lives were found to be low for both constituent of Prethcamide, reaching 7.3 min and 6.5 min for I and II compounds respectively in the blood. They were longest in both cases in the kidney (9.4 min and 8.3 min).

Original languageEnglish
Pages (from-to)47-50
Number of pages4
JournalEuropean Journal of Drug Metabolism and Pharmacokinetics
Volume3
Issue number1
DOIs
Publication statusPublished - Jan 1978

Keywords

  • gas chromatography
  • Pharmacokinetic
  • Prethcamide
  • rats

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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  • Cite this

    Szumilo, T., Canobbio, M. L., Fanelli, R., Mussini, E., & Marcucci, F. (1978). Pharmacokinetic studies of Prethcamide in rats. European Journal of Drug Metabolism and Pharmacokinetics, 3(1), 47-50. https://doi.org/10.1007/BF03189368