Pharmacokinetic studies of Prethcamide in rats

T. Szumilo, M. L. Canobbio, R. Fanelli, E. Mussini, F. Marcucci

Research output: Contribution to journalArticlepeer-review


A simple and sensitive gas chromatographic method for determination of Prethcamide components (I and II) in whole blood and tissues of rats has been developed. The method was used to study disposition of Prethcamide after oral and intravenous administration (60 mg/kg) to rats. Half-lives were found to be low for both constituent of Prethcamide, reaching 7.3 min and 6.5 min for I and II compounds respectively in the blood. They were longest in both cases in the kidney (9.4 min and 8.3 min).

Original languageEnglish
Pages (from-to)47-50
Number of pages4
JournalEuropean Journal of Drug Metabolism and Pharmacokinetics
Issue number1
Publication statusPublished - Jan 1978


  • gas chromatography
  • Pharmacokinetic
  • Prethcamide
  • rats

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)


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