Pharmacokinetic/pharmacodynamic parameters for treatment optimization of infection due to antibiotic resistant bacteria: a summary for practical purposes in children and adults

Research output: Contribution to journalReview article

Abstract

In the last years, there has been a tremendous increase in the incidence of bacterial infections due to resistant strains, especially multi-drug resistant Gram-negative bacilli. In Europe, a north to south and a west to east gradient was noticed, with more than one third of the K. pneumonia isolates being resistant to carbapenems in few countries. New antibiotics are lacking and, as a consequence, pharmacokinetic/pharmacodynamic parameters, normalized to pathogen minimal inhibitory concentration, are used with increased frequency to treat infections due to difficult-to-treat pathogens. These parameters are available at least for the adult population, but sparse in many different publications. This review wants to provide a comprehensive and 'easy to read' text for everyday practice, briefly summarizing the presently available knowledge on pharmacokinetic/pharmacodynamic parameters (normalized for minimal inhibitory concentration values) of different class drugs, that can be applied for an effective antibacterial treatment infections due to antibiotic-resistant pathogens.

Original languageEnglish
Pages (from-to)65-81
Number of pages17
JournalJournal of Chemotherapy
Volume30
Issue number2
DOIs
Publication statusPublished - Apr 2018

Fingerprint

Pharmacokinetics
Anti-Bacterial Agents
Bacteria
Carbapenems
Infection
Bacterial Infections
Pharmaceutical Preparations
Bacillus
Publications
Pneumonia
Incidence
Therapeutics
Population

Keywords

  • Adult
  • Anti-Bacterial Agents/pharmacokinetics
  • Bacteria/drug effects
  • Bacterial Infections/drug therapy
  • Child
  • Drug Resistance, Multiple, Bacterial/drug effects
  • Humans
  • Treatment Outcome

Cite this

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title = "Pharmacokinetic/pharmacodynamic parameters for treatment optimization of infection due to antibiotic resistant bacteria: a summary for practical purposes in children and adults",
abstract = "In the last years, there has been a tremendous increase in the incidence of bacterial infections due to resistant strains, especially multi-drug resistant Gram-negative bacilli. In Europe, a north to south and a west to east gradient was noticed, with more than one third of the K. pneumonia isolates being resistant to carbapenems in few countries. New antibiotics are lacking and, as a consequence, pharmacokinetic/pharmacodynamic parameters, normalized to pathogen minimal inhibitory concentration, are used with increased frequency to treat infections due to difficult-to-treat pathogens. These parameters are available at least for the adult population, but sparse in many different publications. This review wants to provide a comprehensive and 'easy to read' text for everyday practice, briefly summarizing the presently available knowledge on pharmacokinetic/pharmacodynamic parameters (normalized for minimal inhibitory concentration values) of different class drugs, that can be applied for an effective antibacterial treatment infections due to antibiotic-resistant pathogens.",
keywords = "Adult, Anti-Bacterial Agents/pharmacokinetics, Bacteria/drug effects, Bacterial Infections/drug therapy, Child, Drug Resistance, Multiple, Bacterial/drug effects, Humans, Treatment Outcome",
author = "Giulia Gustinetti and Giuliana Cangemi and Roberto Bandettini and Elio Castagnola",
year = "2018",
month = "4",
doi = "10.1080/1120009X.2017.1377909",
language = "English",
volume = "30",
pages = "65--81",
journal = "Journal of Chemotherapy",
issn = "1120-009X",
publisher = "Maney Publishing",
number = "2",

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T1 - Pharmacokinetic/pharmacodynamic parameters for treatment optimization of infection due to antibiotic resistant bacteria

T2 - a summary for practical purposes in children and adults

AU - Gustinetti, Giulia

AU - Cangemi, Giuliana

AU - Bandettini, Roberto

AU - Castagnola, Elio

PY - 2018/4

Y1 - 2018/4

N2 - In the last years, there has been a tremendous increase in the incidence of bacterial infections due to resistant strains, especially multi-drug resistant Gram-negative bacilli. In Europe, a north to south and a west to east gradient was noticed, with more than one third of the K. pneumonia isolates being resistant to carbapenems in few countries. New antibiotics are lacking and, as a consequence, pharmacokinetic/pharmacodynamic parameters, normalized to pathogen minimal inhibitory concentration, are used with increased frequency to treat infections due to difficult-to-treat pathogens. These parameters are available at least for the adult population, but sparse in many different publications. This review wants to provide a comprehensive and 'easy to read' text for everyday practice, briefly summarizing the presently available knowledge on pharmacokinetic/pharmacodynamic parameters (normalized for minimal inhibitory concentration values) of different class drugs, that can be applied for an effective antibacterial treatment infections due to antibiotic-resistant pathogens.

AB - In the last years, there has been a tremendous increase in the incidence of bacterial infections due to resistant strains, especially multi-drug resistant Gram-negative bacilli. In Europe, a north to south and a west to east gradient was noticed, with more than one third of the K. pneumonia isolates being resistant to carbapenems in few countries. New antibiotics are lacking and, as a consequence, pharmacokinetic/pharmacodynamic parameters, normalized to pathogen minimal inhibitory concentration, are used with increased frequency to treat infections due to difficult-to-treat pathogens. These parameters are available at least for the adult population, but sparse in many different publications. This review wants to provide a comprehensive and 'easy to read' text for everyday practice, briefly summarizing the presently available knowledge on pharmacokinetic/pharmacodynamic parameters (normalized for minimal inhibitory concentration values) of different class drugs, that can be applied for an effective antibacterial treatment infections due to antibiotic-resistant pathogens.

KW - Adult

KW - Anti-Bacterial Agents/pharmacokinetics

KW - Bacteria/drug effects

KW - Bacterial Infections/drug therapy

KW - Child

KW - Drug Resistance, Multiple, Bacterial/drug effects

KW - Humans

KW - Treatment Outcome

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VL - 30

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EP - 81

JO - Journal of Chemotherapy

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SN - 1120-009X

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