Abstract
In the last years, there has been a tremendous increase in the incidence of bacterial infections due to resistant strains, especially multi-drug resistant Gram-negative bacilli. In Europe, a north to south and a west to east gradient was noticed, with more than one third of the K. pneumonia isolates being resistant to carbapenems in few countries. New antibiotics are lacking and, as a consequence, pharmacokinetic/pharmacodynamic parameters, normalized to pathogen minimal inhibitory concentration, are used with increased frequency to treat infections due to difficult-to-treat pathogens. These parameters are available at least for the adult population, but sparse in many different publications. This review wants to provide a comprehensive and 'easy to read' text for everyday practice, briefly summarizing the presently available knowledge on pharmacokinetic/pharmacodynamic parameters (normalized for minimal inhibitory concentration values) of different class drugs, that can be applied for an effective antibacterial treatment infections due to antibiotic-resistant pathogens.
Original language | English |
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Pages (from-to) | 65-81 |
Number of pages | 17 |
Journal | Journal of Chemotherapy |
Volume | 30 |
Issue number | 2 |
DOIs | |
Publication status | Published - Apr 2018 |
Keywords
- Adult
- Anti-Bacterial Agents/pharmacokinetics
- Bacteria/drug effects
- Bacterial Infections/drug therapy
- Child
- Drug Resistance, Multiple, Bacterial/drug effects
- Humans
- Treatment Outcome