Abstract
In the last years, there has been a tremendous increase in the incidence of bacterial infections due to resistant strains, especially multi-drug resistant Gram-negative bacilli. In Europe, a north to south and a west to east gradient was noticed, with more than one third of the K. pneumonia isolates being resistant to carbapenems in few countries. New antibiotics are lacking and, as a consequence, pharmacokinetic/pharmacodynamic parameters, normalized to pathogen minimal inhibitory concentration, are used with increased frequency to treat infections due to difficult-to-treat pathogens. These parameters are available at least for the adult population, but sparse in many different publications. This review wants to provide a comprehensive and 'easy to read' text for everyday practice, briefly summarizing the presently available knowledge on pharmacokinetic/pharmacodynamic parameters (normalized for minimal inhibitory concentration values) of different class drugs, that can be applied for an effective antibacterial treatment infections due to antibiotic-resistant pathogens.
| Original language | English |
|---|---|
| Pages (from-to) | 65-81 |
| Number of pages | 17 |
| Journal | Journal of Chemotherapy |
| Volume | 30 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Apr 2018 |
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Keywords
- Adult
- Anti-Bacterial Agents/pharmacokinetics
- Bacteria/drug effects
- Bacterial Infections/drug therapy
- Child
- Drug Resistance, Multiple, Bacterial/drug effects
- Humans
- Treatment Outcome
Cite this
Pharmacokinetic/pharmacodynamic parameters for treatment optimization of infection due to antibiotic resistant bacteria : a summary for practical purposes in children and adults. / Gustinetti, Giulia; Cangemi, Giuliana; Bandettini, Roberto; Castagnola, Elio.
In: Journal of Chemotherapy, Vol. 30, No. 2, 04.2018, p. 65-81.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Pharmacokinetic/pharmacodynamic parameters for treatment optimization of infection due to antibiotic resistant bacteria
T2 - a summary for practical purposes in children and adults
AU - Gustinetti, Giulia
AU - Cangemi, Giuliana
AU - Bandettini, Roberto
AU - Castagnola, Elio
PY - 2018/4
Y1 - 2018/4
N2 - In the last years, there has been a tremendous increase in the incidence of bacterial infections due to resistant strains, especially multi-drug resistant Gram-negative bacilli. In Europe, a north to south and a west to east gradient was noticed, with more than one third of the K. pneumonia isolates being resistant to carbapenems in few countries. New antibiotics are lacking and, as a consequence, pharmacokinetic/pharmacodynamic parameters, normalized to pathogen minimal inhibitory concentration, are used with increased frequency to treat infections due to difficult-to-treat pathogens. These parameters are available at least for the adult population, but sparse in many different publications. This review wants to provide a comprehensive and 'easy to read' text for everyday practice, briefly summarizing the presently available knowledge on pharmacokinetic/pharmacodynamic parameters (normalized for minimal inhibitory concentration values) of different class drugs, that can be applied for an effective antibacterial treatment infections due to antibiotic-resistant pathogens.
AB - In the last years, there has been a tremendous increase in the incidence of bacterial infections due to resistant strains, especially multi-drug resistant Gram-negative bacilli. In Europe, a north to south and a west to east gradient was noticed, with more than one third of the K. pneumonia isolates being resistant to carbapenems in few countries. New antibiotics are lacking and, as a consequence, pharmacokinetic/pharmacodynamic parameters, normalized to pathogen minimal inhibitory concentration, are used with increased frequency to treat infections due to difficult-to-treat pathogens. These parameters are available at least for the adult population, but sparse in many different publications. This review wants to provide a comprehensive and 'easy to read' text for everyday practice, briefly summarizing the presently available knowledge on pharmacokinetic/pharmacodynamic parameters (normalized for minimal inhibitory concentration values) of different class drugs, that can be applied for an effective antibacterial treatment infections due to antibiotic-resistant pathogens.
KW - Adult
KW - Anti-Bacterial Agents/pharmacokinetics
KW - Bacteria/drug effects
KW - Bacterial Infections/drug therapy
KW - Child
KW - Drug Resistance, Multiple, Bacterial/drug effects
KW - Humans
KW - Treatment Outcome
U2 - 10.1080/1120009X.2017.1377909
DO - 10.1080/1120009X.2017.1377909
M3 - Review article
C2 - 29025364
VL - 30
SP - 65
EP - 81
JO - Journal of Chemotherapy
JF - Journal of Chemotherapy
SN - 1120-009X
IS - 2
ER -