TY - JOUR
T1 - Pharmacokinetics and adverse effects of single doses of dothiepin in young and elderly subjects
AU - Bareggi, Silvio R.
AU - Cavallaro, Roberto
AU - Pirola, Rodolfo
AU - Altamura, Alfredo C.
PY - 1990
Y1 - 1990
N2 - 1. The pharmacokinetics and side-effects of Dothiepin (DOT) were studied for four days after administration of a single oral dose of 75 mg to young adult and elderly subjects. 2. In the elderly DOT is absorbed, distributed and eliminated with half-lives about the same as in young adults but it is cleared less efficiently. 3. This difference of clearance in the elderly, after single-dose administration, is not reflected in increased incidence of side-effects.
AB - 1. The pharmacokinetics and side-effects of Dothiepin (DOT) were studied for four days after administration of a single oral dose of 75 mg to young adult and elderly subjects. 2. In the elderly DOT is absorbed, distributed and eliminated with half-lives about the same as in young adults but it is cleared less efficiently. 3. This difference of clearance in the elderly, after single-dose administration, is not reflected in increased incidence of side-effects.
KW - Dothiepin
KW - elderly Pharmacokinetics
UR - http://www.scopus.com/inward/record.url?scp=0025156883&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025156883&partnerID=8YFLogxK
U2 - 10.1016/0278-5846(90)90098-2
DO - 10.1016/0278-5846(90)90098-2
M3 - Article
C2 - 2309034
AN - SCOPUS:0025156883
VL - 14
SP - 163
EP - 170
JO - Progress in Neuro-Psychopharmacology and Biological Psychiatry
JF - Progress in Neuro-Psychopharmacology and Biological Psychiatry
SN - 0278-5846
IS - 2
ER -