Pharmacokinetics and adverse effects of single doses of dothiepin in young and elderly subjects

Silvio R. Bareggi, Roberto Cavallaro, Rodolfo Pirola, Alfredo C. Altamura

Research output: Contribution to journalArticle

Abstract

1. The pharmacokinetics and side-effects of Dothiepin (DOT) were studied for four days after administration of a single oral dose of 75 mg to young adult and elderly subjects. 2. In the elderly DOT is absorbed, distributed and eliminated with half-lives about the same as in young adults but it is cleared less efficiently. 3. This difference of clearance in the elderly, after single-dose administration, is not reflected in increased incidence of side-effects.

Original languageEnglish
Pages (from-to)163-170
Number of pages8
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume14
Issue number2
DOIs
Publication statusPublished - 1990

Keywords

  • Dothiepin
  • elderly Pharmacokinetics

ASJC Scopus subject areas

  • Biological Psychiatry
  • Pharmacology

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