Pharmacokinetics and adverse effects of single doses of dothiepin in young and elderly subjects

Silvio R. Bareggi; Roberto Cavallaro; Rodolfo Pirola; Alfredo C. Altamura

doi:10.1016/0278-5846(90)90098-2

Pharmacokinetics and adverse effects of single doses of dothiepin in young and elderly subjects

Silvio R. Bareggi, Roberto Cavallaro, Rodolfo Pirola, Alfredo C. Altamura

Research output: Contribution to journal › Article

Abstract

1. The pharmacokinetics and side-effects of Dothiepin (DOT) were studied for four days after administration of a single oral dose of 75 mg to young adult and elderly subjects. 2. In the elderly DOT is absorbed, distributed and eliminated with half-lives about the same as in young adults but it is cleared less efficiently. 3. This difference of clearance in the elderly, after single-dose administration, is not reflected in increased incidence of side-effects.

Original language	English
Pages (from-to)	163-170
Number of pages	8
Journal	Progress in Neuro-Psychopharmacology and Biological Psychiatry
Volume	14
Issue number	2
DOIs	https://doi.org/10.1016/0278-5846(90)90098-2
Publication status	Published - 1990

Keywords

Dothiepin
elderly Pharmacokinetics

ASJC Scopus subject areas

Biological Psychiatry
Pharmacology

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Bareggi, S. R., Cavallaro, R., Pirola, R., & Altamura, A. C. (1990). Pharmacokinetics and adverse effects of single doses of dothiepin in young and elderly subjects. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 14(2), 163-170. https://doi.org/10.1016/0278-5846(90)90098-2

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