Abstract
A combined analysis of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) elimination in Seveso adults and Ranch Hand veterans found a period of fast elimination within the first 0.27 years after exposure in Seveso, followed by a period of slower elimination between 3 and 16.35 years from exposure. The mean TCDD elimination rate within the first 0.27 years after exposure among six adult males in the Seveso cohort was 2.0646 year-1 (half-life =0.34 years). The mean rate from 3 to 16.35 years was 0.1011 year-1 (half-life=6.9 years). The mean Ranch Hand elimination rate, 00924 year-1 (half-life=6.9 years), measured between 9 and 33 years after exposure, was significantly less than the Seveso mean in the first 0.27 years after exposure, but not significantly different from the Seveso mean between 3 and 16.35 years after exposure. The fast elimination within the first 0.27 years followed by a slower rate after 3 years is consistent with the expected pattern in a two-compartment open model, with a distribution phase of rapid elimination followed by a slower elimination phase.
| Original language | English |
|---|---|
| Pages (from-to) | 44-53 |
| Number of pages | 10 |
| Journal | Journal of Exposure Analysis and Environmental Epidemiology |
| Volume | 12 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2002 |
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Keywords
- Agent Orange
- Dioxin
- Pharmacokinetics
- TCDD
ASJC Scopus subject areas
- Environmental Science(all)
- Environmental Chemistry
- Public Health, Environmental and Occupational Health
- Pollution
- Toxicology
- Health, Toxicology and Mutagenesis
Cite this
Pharmacokinetics of 2,3,7,8-tetrachlorodibenzo-p-dioxin in Seveso adults and veterans of operation Ranch Hand. / Michalek, Joel E.; Pirkle, James L.; Needham, Larry L.; Patterson, Donald G.; Caudill, Samuel P.; Tripathi, Ram C.; Mocarelli, Paolo.
In: Journal of Exposure Analysis and Environmental Epidemiology, Vol. 12, No. 1, 2002, p. 44-53.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pharmacokinetics of 2,3,7,8-tetrachlorodibenzo-p-dioxin in Seveso adults and veterans of operation Ranch Hand
AU - Michalek, Joel E.
AU - Pirkle, James L.
AU - Needham, Larry L.
AU - Patterson, Donald G.
AU - Caudill, Samuel P.
AU - Tripathi, Ram C.
AU - Mocarelli, Paolo
PY - 2002
Y1 - 2002
N2 - A combined analysis of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) elimination in Seveso adults and Ranch Hand veterans found a period of fast elimination within the first 0.27 years after exposure in Seveso, followed by a period of slower elimination between 3 and 16.35 years from exposure. The mean TCDD elimination rate within the first 0.27 years after exposure among six adult males in the Seveso cohort was 2.0646 year-1 (half-life =0.34 years). The mean rate from 3 to 16.35 years was 0.1011 year-1 (half-life=6.9 years). The mean Ranch Hand elimination rate, 00924 year-1 (half-life=6.9 years), measured between 9 and 33 years after exposure, was significantly less than the Seveso mean in the first 0.27 years after exposure, but not significantly different from the Seveso mean between 3 and 16.35 years after exposure. The fast elimination within the first 0.27 years followed by a slower rate after 3 years is consistent with the expected pattern in a two-compartment open model, with a distribution phase of rapid elimination followed by a slower elimination phase.
AB - A combined analysis of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) elimination in Seveso adults and Ranch Hand veterans found a period of fast elimination within the first 0.27 years after exposure in Seveso, followed by a period of slower elimination between 3 and 16.35 years from exposure. The mean TCDD elimination rate within the first 0.27 years after exposure among six adult males in the Seveso cohort was 2.0646 year-1 (half-life =0.34 years). The mean rate from 3 to 16.35 years was 0.1011 year-1 (half-life=6.9 years). The mean Ranch Hand elimination rate, 00924 year-1 (half-life=6.9 years), measured between 9 and 33 years after exposure, was significantly less than the Seveso mean in the first 0.27 years after exposure, but not significantly different from the Seveso mean between 3 and 16.35 years after exposure. The fast elimination within the first 0.27 years followed by a slower rate after 3 years is consistent with the expected pattern in a two-compartment open model, with a distribution phase of rapid elimination followed by a slower elimination phase.
KW - Agent Orange
KW - Dioxin
KW - Pharmacokinetics
KW - TCDD
UR - http://www.scopus.com/inward/record.url?scp=0036175569&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036175569&partnerID=8YFLogxK
U2 - 10.1038/sj/jea/7500201
DO - 10.1038/sj/jea/7500201
M3 - Article
C2 - 11859432
AN - SCOPUS:0036175569
VL - 12
SP - 44
EP - 53
JO - Journal of Exposure Analysis and Environmental Epidemiology
JF - Journal of Exposure Analysis and Environmental Epidemiology
SN - 1053-4245
IS - 1
ER -