Pharmacokinetics of 2,3,7,8-tetrachlorodibenzo-p-dioxin in Seveso adults and veterans of operation Ranch Hand

Joel E. Michalek, James L. Pirkle, Larry L. Needham, Donald G. Patterson, Samuel P. Caudill, Ram C. Tripathi, Paolo Mocarelli

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

A combined analysis of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) elimination in Seveso adults and Ranch Hand veterans found a period of fast elimination within the first 0.27 years after exposure in Seveso, followed by a period of slower elimination between 3 and 16.35 years from exposure. The mean TCDD elimination rate within the first 0.27 years after exposure among six adult males in the Seveso cohort was 2.0646 year-1 (half-life =0.34 years). The mean rate from 3 to 16.35 years was 0.1011 year-1 (half-life=6.9 years). The mean Ranch Hand elimination rate, 00924 year-1 (half-life=6.9 years), measured between 9 and 33 years after exposure, was significantly less than the Seveso mean in the first 0.27 years after exposure, but not significantly different from the Seveso mean between 3 and 16.35 years after exposure. The fast elimination within the first 0.27 years followed by a slower rate after 3 years is consistent with the expected pattern in a two-compartment open model, with a distribution phase of rapid elimination followed by a slower elimination phase.

Original languageEnglish
Pages (from-to)44-53
Number of pages10
JournalJournal of Exposure Analysis and Environmental Epidemiology
Volume12
Issue number1
DOIs
Publication statusPublished - 2002

Fingerprint

Pharmacokinetics
Veterans
dioxin
Half-Life
Hand
half life
Polychlorinated Dibenzodioxins
exposure
pharmacokinetics
1,4-dioxin
rate

Keywords

  • Agent Orange
  • Dioxin
  • Pharmacokinetics
  • TCDD

ASJC Scopus subject areas

  • Environmental Science(all)
  • Environmental Chemistry
  • Public Health, Environmental and Occupational Health
  • Pollution
  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Michalek, J. E., Pirkle, J. L., Needham, L. L., Patterson, D. G., Caudill, S. P., Tripathi, R. C., & Mocarelli, P. (2002). Pharmacokinetics of 2,3,7,8-tetrachlorodibenzo-p-dioxin in Seveso adults and veterans of operation Ranch Hand. Journal of Exposure Analysis and Environmental Epidemiology, 12(1), 44-53. https://doi.org/10.1038/sj/jea/7500201

Pharmacokinetics of 2,3,7,8-tetrachlorodibenzo-p-dioxin in Seveso adults and veterans of operation Ranch Hand. / Michalek, Joel E.; Pirkle, James L.; Needham, Larry L.; Patterson, Donald G.; Caudill, Samuel P.; Tripathi, Ram C.; Mocarelli, Paolo.

In: Journal of Exposure Analysis and Environmental Epidemiology, Vol. 12, No. 1, 2002, p. 44-53.

Research output: Contribution to journalArticle

Michalek, Joel E. ; Pirkle, James L. ; Needham, Larry L. ; Patterson, Donald G. ; Caudill, Samuel P. ; Tripathi, Ram C. ; Mocarelli, Paolo. / Pharmacokinetics of 2,3,7,8-tetrachlorodibenzo-p-dioxin in Seveso adults and veterans of operation Ranch Hand. In: Journal of Exposure Analysis and Environmental Epidemiology. 2002 ; Vol. 12, No. 1. pp. 44-53.
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