The pharmacokinetics of amitryptyline (AMI) have been evaluated in six healthy elderly volunteers (72-83 years of age) after a single oral dose of 125 mg of AMI-HCl. AMI was absorbed rather slowly (mean peak time 10.4±1.6 hrs) but very efficiently (F: 0.59-0.75). The rate of formation of nortriptyline (NT) as well as the apparent clearance values (0.18-0.45 l/h/kg) of AMI were significantly lower than those previously described for younger subjects. Reversible alterating ECG were observed in 5 cases concomitantly with AMI peak plasma concentrations. The results indicate the desirability of reduced and/or divided daily doses of AMI in the elderly.
|Number of pages||5|
|Journal||International Journal of Clinical Pharmacology Therapy and Toxicology|
|Publication status||Published - 1981|
ASJC Scopus subject areas
- Pharmacology (medical)