Pharmacokinetics of amitriptyline in the elderly

J. F. Henry, C. Altamura, R. Gomeni, M. P. Hervy, F. Forette, P. L. Morselli

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The pharmacokinetics of amitryptyline (AMI) have been evaluated in six healthy elderly volunteers (72-83 years of age) after a single oral dose of 125 mg of AMI-HCl. AMI was absorbed rather slowly (mean peak time 10.4±1.6 hrs) but very efficiently (F: 0.59-0.75). The rate of formation of nortriptyline (NT) as well as the apparent clearance values (0.18-0.45 l/h/kg) of AMI were significantly lower than those previously described for younger subjects. Reversible alterating ECG were observed in 5 cases concomitantly with AMI peak plasma concentrations. The results indicate the desirability of reduced and/or divided daily doses of AMI in the elderly.

Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalInternational Journal of Clinical Pharmacology Therapy and Toxicology
Issue number1
Publication statusPublished - 1981

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology (medical)


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