Pharmacokinetics of atenolol in hypertensive subjects with and without co-administration of chlorthalidone

E. Riva, P. L. Farina, R. Sega, G. Tognoni, W. Bastain, J. McAinsh

Research output: Contribution to journalArticlepeer-review

Abstract

The pharmacokinetics of atenolol with and without the co-administration of chlorthalidone were studied in five hypertensive subjects. Concomitant administration of chlorthalidone appears to have little if any effect on the pharmacokinetics of atenolol during treatment for 7 days. The atenolol elimination half-lives were 6.7±1.1 and 6.3±0.9 h, respectively, with and without chlorthalidone. Two healthy volunteers also received a single 50 mg oral dose of chlorthalidone. Their blood profiles and pharmacokinetics were similar to those observed in hypertensive subjects, but a statistically significant difference (p

Original languageEnglish
Pages (from-to)333-337
Number of pages5
JournalEuropean Journal of Clinical Pharmacology
Volume17
Issue number5
DOIs
Publication statusPublished - Sep 1980

Keywords

  • atenolol
  • chlorthalidone
  • chronic treatment
  • co-administration
  • hypertension
  • plasma half-life
  • urine half-life

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)

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