Pharmacokinetics of etoposide in gestochoriocarcinoma

M. D'Incalci, C. Sessa, C. Rossi, G. Roviaro, C. Mangioni

Research output: Contribution to journalArticlepeer-review

Abstract

Etoposide (VP16) levels were determined by high-performance liquid chromatography assay in plasma, urine, and surgical specimens of patients with choriocarcinoma undergoing surgery after a dose of 100 or 200 mg/m2 given as a 1-hour infusion. The drug disappeared from plasma biexponentially, with a terminal half-life of 4.1 ± 0.4 hours, an apparent volume of distribution of 9 ± 1.1 L/m2, and clearance of 21.5 ± 3.1 ml/minute/m2. Fifty and 740 minutes after the end of VP16 infusion, the drug concentrations in myometrial carcinoma or in normal myometrium were approximately 40%-50% of those in plasma; 25-180 minutes after the end of drug infusion, the concentrations of VP16 in lung metastases amounted to 19%-43% of those in plasma, whereas in normal lung, the concentrations of VP16 were 38%-61% of those in plasma. In subcutaneous tissue, VP16 levels were much lower than in plasma (about 5%-27%). About 50% of VP16 was eliminated in the urine as unchanged drug, glucuronide, or sulfate.

Original languageEnglish
Pages (from-to)69-72
Number of pages4
JournalCancer Treatment Reports
Volume69
Issue number1
Publication statusPublished - 1985

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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